The association between white matter tract structural connectivity and information processing speed in relapsing-remitting multiple sclerosis.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2023-09-01 Epub Date: 2023-04-27 DOI:10.1007/s10072-023-06817-6

Magdalena Chylińska, Bartosz Karaszewski, Jakub Komendziński, Adam Wyszomirski, Marek Hałas, Edyta Szurowska, Agnieszka Sabisz

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引用次数: 0

Abstract

Background: Information processing speed (IPS) deterioration is common in relapsing-remitting multiple sclerosis (RRMS) patients [1] and might severely affect quality of life and occupational activity. However, understanding of its neural substrate is not fully elucidated. We aimed to investigate the associations between MRI-derived metrics of neuroanatomical structures, including the tracts, and IPS.

Methods: Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT), and Color Trails Test (CTT) were used to evaluate IPS in 73 RRMS consecutive patients, all undergoing only interferon beta (IFN-β) therapy during the study. At the same time, 1.5T MRI including diffusion tensor imaging (DTI) data was acquired for each recruited subject. We analyzed volumetric and diffusion MRI measures (FreeSurfer 6.0) including normalized brain volume (NBV), cortical thickness (thk), white matter hypointensities (WMH), volume (vol), diffusion parameters: mean (MD), radial (RD), axial (AD) diffusivities, and fractional anisotropy (FA) of 18 major white-matter (WM) tracts. Multiple linear regression model with interaction resulted in distinguishing the neural substrate of IPS deficit in the IPS impaired subgroup of patients.

Results: The most significant tract abnormalities contributing to IPS deficit were right inferior longitudinal fasciculus (R ILF) FA, forceps major (FMAJ) FA, forceps minor (FMIN) FA, R uncinate fasciculus (UNC) AD, R corticospinal tract (CST) FA, and left superior longitudinal fasciculus FA (L SLFT). Among volumetric MRI metrics, IPS deficit was associated with L and R thalamic vol. and cortical thickness of insular regions.

Conclusion: In this study, we showed that disconnection of the selected WM tracts, in addition to cortical and deep gray matter (GM) atrophy, might underlie IPS deficit in RRMS patients but more extensive studies are needed for precise associations.

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复发缓解型多发性硬化症患者白质束结构连通性与信息处理速度之间的关联。

背景：信息处理速度（IPS）下降在复发缓解型多发性硬化症（RRMS）患者中很常见[1]，可能会严重影响生活质量和职业活动。然而，人们对其神经基质的认识尚未完全阐明。我们旨在研究包括神经束在内的神经解剖结构的 MRI 衍生指标与 IPS 之间的关联：符号数字模型测试（SDMT）、步调听觉连续加法测试（PASAT）和颜色轨迹测试（CTT）用于评估73例RRMS连续患者的IPS，所有患者在研究期间都只接受了干扰素β（IFN-β）治疗。与此同时，我们还为每位受试者采集了包括弥散张量成像（DTI）数据在内的 1.5T MRI。我们分析了容积和弥散 MRI 测量（FreeSurfer 6.0），包括归一化脑容量（NBV）、皮质厚度（thk）、白质低密度（WMH）、容积（vol）、弥散参数：平均（MD）、径向（RD）、轴向（AD）弥散和 18 条主要白质（WM）束的分数各向异性（FA）。多重线性回归模型与交互作用的结果区分了IPS受损亚组患者IPS缺陷的神经基质：结果：导致IPS缺失的最重要神经束异常是右下纵筋束（R ILF）FA、大镊子（FMAJ）FA、小镊子（FMIN）FA、R钩状筋束（UNC）AD、R皮质脊髓束（CST）FA和左上纵筋束FA（L SLFT）。在核磁共振成像容积指标中，IPS 缺陷与丘脑左侧和右侧容积以及岛叶区皮质厚度相关：在这项研究中，我们发现，除了皮质和深部灰质（GM）萎缩外，选定的WM束断开可能是RRMS患者IPS缺失的原因，但需要进行更广泛的研究以获得精确的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.