Volume-based 18F-fluorodeoxyglucose positron emission tomography/computed tomography parameters correlate with delayed neck metastasis in clinical early-stage oral squamous cell carcinoma.

IF 1.6 3区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Oral Radiology Pub Date : 2023-10-01 Epub Date: 2023-04-21 DOI:10.1007/s11282-023-00686-7
Nobuhiro Yamakawa, Yohei Nakayama, Nobuhiro Ueda, Takahiro Yagyuu, Shigehiro Tamaki, Tadaaki Kirita
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引用次数: 0

Abstract

Objective: There is no known preoperative marker that can effectively predict the risk of delayed neck metastasis (DNM), which is an important factor that determines the prognosis of early-stage oral cancer. In this study, we examined whether 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET)/computed tomography (CT) uptake parameters of primary cancer can predict the risk of DNM in early-stage oral squamous cell carcinoma (OSCC).

Methods: Data from patients with stage I-II OSCC who underwent surgical resection of the primary tumor without elective neck dissection between January 2009 and December 2016 were retrospectively reviewed. Patient characteristics, histopathological factors, and PET/CT parameters (maximum standardized uptake value [SUVmax], metabolic tumor volume [MTV], and total lesion glycolysis [TLG]) were evaluated for their association with DNM. DNM rates were calculated, and the parameters that were statistically significant in the univariate analysis were used as explanatory variables. Independent factors associated with DNM were identified using multivariate analysis. For all statistical analyses, p-values < 0.05 were considered statistically significant.

Results: Data from 71 patients were analyzed in the study. The overall DNM rate among all patients was 21.8%. The univariate analysis showed that the T classification, depth of invasion, pattern of invasion, lymphovascular invasion, SUVmax, MTV, and TLG were significant predictors of DNM. However, the multivariate analysis revealed that only the depth of invasion, MTV, and TLG were independent predictors of DNM.

Conclusion: This study suggests that, in addition to conventional predictors, volume-based PET parameters are useful predictors of DNM in those with early-stage OSCC.

Abstract Image

基于体积的18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描参数与临床早期口腔鳞状细胞癌延迟颈部转移相关。
目的:目前尚没有明确的术前标志物能有效预测早期口腔癌症颈转移(DNM)的风险,而延迟颈转移是决定早期口腔癌预后的重要因素。在本研究中,我们研究了原发性癌症的18F-氟脱氧葡萄糖正电子发射断层扫描(18F-FDG-PET)/计算机断层扫描(CT)摄取参数是否可以预测早期口腔鳞状细胞癌(OSCC)中DNM的风险对2016年进行了回顾性审查。评估患者特征、组织病理学因素和PET/CT参数(最大标准化摄取值[SUVmax]、代谢肿瘤体积[MTV]和总病变糖酵解[TLG])与DNM的关系。计算DNM发生率,并将单变量分析中具有统计学意义的参数用作解释变量。使用多变量分析确定了与DNM相关的独立因素。对于所有统计分析,p值 结果:对71例患者的数据进行了分析。所有患者的总DNM发生率为21.8%。单因素分析显示,T分类、侵袭深度、侵袭模式、淋巴血管侵袭、SUVmax、MTV和TLG是DNM的重要预测因素。然而,多变量分析显示,只有浸润深度、MTV和TLG是DNM的独立预测因素。结论:本研究表明,除了传统的预测因素外,基于体积的PET参数是早期OSCC患者DNM的有用预测因素。
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来源期刊
Oral Radiology
Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.20
自引率
13.60%
发文量
87
审稿时长
>12 weeks
期刊介绍: As the official English-language journal of the Japanese Society for Oral and Maxillofacial Radiology and the Asian Academy of Oral and Maxillofacial Radiology, Oral Radiology is intended to be a forum for international collaboration in head and neck diagnostic imaging and all related fields. Oral Radiology features cutting-edge research papers, review articles, case reports, and technical notes from both the clinical and experimental fields. As membership in the Society is not a prerequisite, contributions are welcome from researchers and clinicians worldwide.
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