Non-Gaussian model-based diffusion-weighted imaging of oral squamous cell carcinoma: associations with Ki-67 proliferation status.

IF 1.6 3区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Radiology Pub Date : 2023-10-01 Epub Date: 2023-03-27 DOI:10.1007/s11282-023-00682-x

Tomoka Shima, Noriyuki Fujima, Shigeru Yamano, Hiroyuki Kameda, Masaaki Suzuka, Akiko Takeuchi, Yurika Kinoshita, Nanami Iwai, Kohsuke Kudo, Kazuyuki Minowa

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引用次数: 1

Abstract

Objectives: To investigate possible associations between diffusion-weighted imaging (DWI) parameters derived from a non-Gaussian model fitting and Ki-67 status in patients with oral squamous cell carcinoma (OSCC).

Methods: Twenty-four patients with newly diagnosed OSCC were prospectively recruited. DWI was performed using six b-values (0-2500). The diffusion-related parameters of kurtosis value (K), kurtosis-corrected diffusion coefficient (D_K), diffusion heterogeneity (α), distributed diffusion coefficient (DDC), slow diffusion coefficient (D_slow), and apparent diffusion coefficient (ADC) were calculated from four diffusion fitting models. Ki-67 status was categorized as low (Ki-67 percentage score < 20%), middle (20-50%), or high (> 50%). Kruskal-Wallis tests were performed between each non-Gaussian diffusion model parameters and Ki-67 grade.

Results: The Kruskal-Wallis tests revealed that multiple parameters (K, ADC, D_k, DDC and D_slow) showed statistically significant differences between the three levels of Ki-67 status (K: p = 0.020, ADC: p = 0.012, D_k: p = 0.027, DDC: p = 0.007 and D_slow: p = 0.026).

Conclusions: Several non-Gaussian diffusion model parameters and ADC values were significantly associated with Ki-67 status and have potential as promising prognostic biomarkers in patients with OSCC.

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口腔鳞状细胞癌的非高斯模型扩散加权成像：与Ki-67增殖状态的关系。

目的：研究口腔鳞状细胞癌（OSCC）患者的非高斯模型拟合扩散加权成像（DWI）参数与Ki-67状态之间的可能关系。DWI使用6个b值（0-2500）进行。从四个扩散拟合模型计算了峰度值（K）、峰度校正扩散系数（DK）、扩散不均匀性（α）、分布扩散系数（DDC）、慢扩散系数（Dslow）和表观扩散系数（ADC）的扩散相关参数。Ki-67状态被归类为低（Ki-67百分比得分 50%）。在每个非高斯扩散模型参数和Ki-67等级之间进行Kruskal-Wallis检验。结果：Kruskal-Wallis检验显示，多个参数（K、ADC、Dk、DDC和Dslow）显示Ki-67状态的三个水平之间存在统计学显著差异（K:p = 0.020，ADC:p = 0.012，Dk:p = 0.027，DDC:p = 0.007和Dslow:p = 0.026）。结论：几个非高斯扩散模型参数和ADC值与Ki-67状态显著相关，并有可能成为OSCC患者有前景的预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.20

自引率

13.60%

发文量

审稿时长

>12 weeks

期刊介绍： As the official English-language journal of the Japanese Society for Oral and Maxillofacial Radiology and the Asian Academy of Oral and Maxillofacial Radiology, Oral Radiology is intended to be a forum for international collaboration in head and neck diagnostic imaging and all related fields. Oral Radiology features cutting-edge research papers, review articles, case reports, and technical notes from both the clinical and experimental fields. As membership in the Society is not a prerequisite, contributions are welcome from researchers and clinicians worldwide.