Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis.

IF 2.7 4区医学 Q1 ORTHOPEDICS

CARTILAGE Pub Date : 2024-09-01 Epub Date: 2023-06-13 DOI:10.1177/19476035231172152

Julie Legrand, Claire Marzin, Tuhina Neogi, Laurène Norberciak, Jean-François Budzik, Tristan Pascart

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引用次数: 0

Abstract

Objective: To characterize dual-energy computed tomography (DECT) changes depicting hyaline cartilage changes in gout patients with and without osteoarthritis (OA) and in comparators without gout.

Design: Patients with suspected crystal-associated arthropathy were enrolled and underwent bilateral DECT scans of the knees. Standardized regions of interest were defined in the femorotibial hyaline cartilage. Five DECT parameters were obtained: CT numbers in Hounsfield units (HU) at 80 and 140 kV, the electron density (Rho), the effective atomic number (Z_eff), and the dual-energy index (DEI). Zones were compared between patients with gout, with and without knee OA, and between patients with gout and comparators without gout, after adjustment for confounders.

Results: A total of 113 patients with gout (mean age 63.5 ± 14.3 years) and 15 comparators without gout (mean age 75.8 ± 11.5 years) were included, n = 65 (51%) had knee OA, and 466 zones of hyaline cartilage were analyzed. Older age was associated with lower attenuations at 80 kV (P < 0.01) and 140 kV (P < 0.01), and with Rho (P < 0.01). OA was characterized by lower attenuation at 140 kV (P = 0.03), but the lower Rho was nonsignificant after adjustment for confounders. In gout, hyaline cartilage exhibited lower Rho values (adjusted P = 0.04). Multivariable coefficients of association with Rho were -0.21 [-0.38;-0.04] (P = 0.014) for age, -4.15 [-9.0;0.7] (P = 0.093) for OA and 0.73 [-0.1;1.56] (P = 0.085) for monosodium urate volume.

Conclusion: Gout was associated with DECT-detected changes in cartilage composition, similar to those observed in older patients, with some similarities and some differences to those seen in OA. These results suggest the possibility of potential DECT biomarkers of OA.

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用双能量计算机断层扫描测量痛风、衰老和骨关节炎患者膝关节透明软骨成分变化的关联性

目的描述伴有或不伴有骨关节炎（OA）的痛风患者以及无痛风的比较者的双能计算机断层扫描（DECT）描述透明软骨变化的特征：设计：招募疑似晶体相关性关节病患者，对其双侧膝关节进行 DECT 扫描。在股胫骨透明软骨中定义了标准化的感兴趣区。获得了五个 DECT 参数：在 80 和 140 千伏电压下以 HU 为单位的 CT 数值、电子密度 (Rho)、有效原子序数 (Zeff) 和双能指数 (DEI)。在对混杂因素进行调整后，比较了痛风患者、膝关节OA患者和非膝关节OA患者之间的区域，以及痛风患者和非痛风患者比较者之间的区域：共纳入了113名痛风患者（平均年龄为63.5 ± 14.3岁）和15名无痛风的比较者（平均年龄为75.8 ± 11.5岁），其中65人（51%）患有膝关节OA，共分析了466个透明软骨区。年龄越大，80 kV（P < 0.01）和 140 kV（P < 0.01）的衰减越低，Rho（P < 0.01）也越低。OA 在 140 kV 的衰减较低（P = 0.03），但在调整混杂因素后，较低的 Rho 并不显著。痛风患者的透明软骨显示出较低的 Rho 值（调整后 P = 0.04）。年龄与Rho的多变量相关系数为-0.21[-0.38;-0.04]（P = 0.014），OA为-4.15[-9.0;0.7]（P = 0.093），尿酸单钠含量为0.73[-0.1;1.56]（P = 0.085）：痛风与DECT检测到的软骨成分变化有关，与老年患者中观察到的变化相似，与OA中观察到的变化有一些相似之处，也有一些不同之处。这些结果表明，DECT有可能成为OA的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.