Separation of memory span and learning rate: Evidence from behavior and spontaneous brain activity in older adults.

Abstract

It is unclear how the ability to initially acquire information in a first learning trial relates to learning rate in subsequent repeated trials. The separation of memory span and learning rate is an important psychological dilemma that remains unaddressed. Given the potential effects of aging on memory and learning, this study investigated the separation of memory span and learning rate from behavior and spontaneous brain activity in older adults. We enrolled a total of 758 participants, including 707 healthy older adults and 51 mild cognitive impairment (MCI) patients. Sixty-five participants out of 707 completed resting-state functional magnetic resonance imaging (fMRI) scanning. Behaviorally, memory span and learning rate were not correlated with each other in the paired-associative learning test (PALT) but were negatively correlated in the auditory verbal learning test (AVLT). This indicated that the relationship between memory span and learning rate for item memory might be differentially affected by aging. Interaction analysis confirmed that these two capacities were differentially affected by test type (associative memory vs. item memory). Additionally, at three progressive brain activity indexes (ALFF, ReHo, and DC), the right brain regions (right inferior temporal gyrus and right middle frontal gyrus) were more negatively correlated with memory span, whereas, the left precuneus was more positively correlated with learning rate. Regarding pathological aging, none of the correlations between memory span and learning rate were significant in either PALT or AVLT in MCI. This study provides novel evidence for the dissociation of memory span and learning rate at behavioral and brain activity levels, which may have useful applications in detecting cognitive deficits or conducting cognitive interventions.