Therapeutic Potential of PTBP1 Inhibition, If Any, Is Not Attributed to Glia-to-Neuron Conversion.

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-02-07 DOI:10.1146/annurev-neuro-092822-083410
Lei-Lei Wang, Chun-Li Zhang
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引用次数: 0

Abstract

A holy grail of regenerative medicine is to replenish the cells that are lost due to disease. The adult mammalian central nervous system (CNS) has, however, largely lost such a regenerative ability. An emerging strategy for the generation of new neurons is through glia-to-neuron (GtN) conversion in vivo, mainly accomplished by the regulation of fate-determining factors. When inhibited, PTBP1, a factor involved in RNA biology, was reported to induce rapid and efficient GtN conversion in multiple regions of the adult CNS. Remarkably, PTBP1 inhibition was also claimed to greatly improve behaviors of mice with neurological diseases or aging. These phenomenal claims, if confirmed, would constitute a significant advancement in regenerative medicine. Unfortunately, neither GtN conversion nor therapeutic potential via PTBP1 inhibition was validated by the results of multiple subsequent replication studies with stringent methods. Here we review these controversial studies and conclude with recommendations for examining GtN conversion in vivo and future investigations of PTBP1.

PTBP1抑制的治疗潜力(如果有的话)不归因于神经胶质转化。
再生医学的圣杯是补充因疾病而失去的细胞。然而,成年哺乳动物中枢神经系统(CNS)在很大程度上已经失去了这种再生能力。产生新神经元的一种新策略是通过体内神经胶质到神经元(GtN)的转化,主要通过调节命运决定因子来实现。据报道,当被抑制时,参与RNA生物学的因子PTBP1可在成人中枢神经系统的多个区域诱导快速有效的GtN转化。值得注意的是,PTBP1的抑制也被认为可以极大地改善患有神经疾病或衰老的小鼠的行为。这些惊人的说法,如果得到证实,将构成再生医学的重大进步。不幸的是,无论是GtN转化还是通过PTBP1抑制的治疗潜力,都没有通过随后使用严格方法进行的多次复制研究的结果得到验证。在这里,我们回顾了这些有争议的研究,并提出了在体内检查GtN转化和PTBP1未来研究的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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