Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis.

IF 13.6 1区 生物学 Q1 CELL BIOLOGY
Li Chen, Liping Zhang, Xujun Ye, Zixin Deng, Changming Zhao
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引用次数: 0

Abstract

Ergothioneine, Ovothiol, and Selenoneine are sulfur/selenium-containing histidine-derived natural products widely distributed across different organisms. They exhibit significant antioxidant properties, making them as potential lead compounds for promoting health. Increasing evidence suggests that Ergothioneine is positively correlated with healthy ageing and longevity. The mechanisms underlying Ergothioneine's regulation of the ageing process at cellular and molecular levels are beginning to be understood. In this review, we provide an in-depth and extensive coverage of the anti-ageing studies on Ergothioneine and discuss its possible intracellular targeting pathways. In addition, we highlight the recent efforts in elucidating the biosynthetic details for Ergothioneine, Ovothiol, and Selenoneine, with a particular focus on the study of their pharmacophore-forming enzymology.

麦角硫因及其同系物:抗衰老机制和药源生物合成。
麦角硫因、Ovothiol 和硒酮是含硫/硒的组氨酸衍生天然产物,广泛分布于不同生物体内。它们具有明显的抗氧化特性,是促进健康的潜在先导化合物。越来越多的证据表明,麦角硫因与健康老龄化和长寿呈正相关。人们开始了解麦角硫因在细胞和分子水平上调节衰老过程的机制。在这篇综述中,我们深入而广泛地介绍了麦角硫因的抗衰老研究,并讨论了其可能的细胞内靶向途径。此外,我们还重点介绍了最近在阐明麦角硫因、Ovothiol 和硒酮的生物合成细节方面所做的努力,尤其是对其药效形成酶学的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Protein & Cell
Protein & Cell CELL BIOLOGY-
CiteScore
24.00
自引率
0.90%
发文量
1029
审稿时长
6-12 weeks
期刊介绍: Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.
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