Heart rate stability in a clinical setting and after a short exercise in healthy male volunteers

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging Pub Date : 2023-07-17 DOI:10.1111/cpf.12846

Fleur W. H. Wildenbeest, Gert-Jan Hassing, Michiel J. B. Kemme, Matthijs Moerland, Pim Gal

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引用次数: 0

Abstract

Introduction

Limited data exist on heart rate stabilization in the domiciled nature of phase I clinical studies, particularly when frequent measurements of QT intervals are involved. The present analysis aimed to evaluate heart rate stability in the domiciled nature of, and stabilization after a short exercise.

Methods

Fifty-six healthy male subjects were included in this analysis. Data during a domiciled clinical setting and after a short exercise were analysed. Mean values of 30 s intervals of collected electrocardiographical data (PR, RR, QT and QTcF intervals) during a 10-min supine resting period in a domiciled nature or after walking up and down three stories (100 steps) were compared to baseline values using paired t-tests or compared to the intrasubject standard deviation.

Results

Stable heart rates and stable QTcF intervals observed immediately upon assuming a supine position in the domiciled clinical setting. After the short exercise, PR interval and RR interval were significantly (p < 0.05) shorter for up to 120 s (mean value −9.8 ± 7.2 ms) and 30 s (−160 ± 165 ms, p < 0.05), respectively. QT and QTcF intervals were significantly (p < 0.05) shorter for up to 90 and 120 s postexercise, respectively. Both QT and QTcF intervals stabilized after 2 min, but QT interval remained prolonged while QTcF interval returned to baseline levels.

Conclusion

In a clinical setting, male volunteers do not require a waiting period for electrocardiographic parameter normalization. However, accurate measurement of these parameters following a short exercise necessitates a minimum 2-min resting interval.

Abstract Image

查看原文本刊更多论文

健康男性志愿者在临床环境和短暂运动后的心率稳定性。

引言:在I期临床研究中，关于心率稳定的数据有限，特别是当频繁测量QT间期时。本分析的目的是评估在固定状态下的心率稳定性，以及短时间运动后的稳定性。方法:对56名健康男性进行分析。数据在一个固定的临床设置和短暂的锻炼后进行分析。使用配对t检验或与受试者内标准差比较在居住环境中10分钟仰卧休息期间或上下三层楼(100步)后收集的心电图数据(PR、RR、QT和QTcF间隔)间隔30 s的平均值。结果:稳定的心率和稳定的QTcF间隔观察立即采取仰卧位在住家的临床设置。结论:在临床环境下，男性志愿者不需要等待心电图参数归一化的时间。然而，在短时间运动后准确测量这些参数需要至少2分钟的休息间隔。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.