Sleep apnea and cardiovascular risk.

IF 2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Opinion in Cardiology Pub Date : 2023-09-01 DOI:10.1097/HCO.0000000000001065

Manu Rajachandran, Nils Nickel, Richard A Lange

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引用次数: 2

Abstract

Purpose of review: Obstructive sleep apnea (OSA) is associated with several cardiovascular risk predictors that have only recently begun to be studied in detail. The strong association between OSA and hypertension, coronary artery disease, congestive heart failure, and sudden cardiac death underscores its significant impact on cardiovascular health. This brief review considers the links between OSA and cardiovascular risk.

Recent findings: OSA is an important contributor to endothelial dysfunction and damage, while repetitive hypoxia and hypercarbia contribute to autonomic dysfunction and sympathetic stimulation. In turn, these derangements have deleterious hematologic effects, including hypercoagulability and abnormal platelet aggregability, which are important in the pathogenesis of atherothrombotic disease.

Summary: The varied deleterious effects of OSA on cardiovascular health stem from a unique 'perfect storm' of hypoxic oxidative stress, autonomic dysregulation, endothelial damage, and inflammation occurring at the microvascular level. Further research may disentangle these multiple etiologic threads and provide a better understanding of the underlying pathophysiological relationship between OSA and cardiovascular disease.

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睡眠呼吸暂停和心血管风险。

综述目的:阻塞性睡眠呼吸暂停(OSA)与几种心血管风险预测因素相关，这些因素最近才开始被详细研究。阻塞性睡眠呼吸暂停与高血压、冠状动脉疾病、充血性心力衰竭和心源性猝死之间的密切联系强调了其对心血管健康的重要影响。本文简要回顾了阻塞性睡眠呼吸暂停与心血管疾病风险之间的联系。最近的研究发现:OSA是内皮功能障碍和损伤的重要因素，而重复缺氧和高碳可导致自主神经功能障碍和交感神经刺激。反过来，这些紊乱具有有害的血液学影响，包括高凝性和血小板聚集性异常，这在动脉粥样硬化性血栓形成疾病的发病机制中很重要。摘要:OSA对心血管健康的各种有害影响源于缺氧氧化应激、自主神经失调、内皮损伤和微血管水平炎症的独特“完美风暴”。进一步的研究可能会解开这些多重病因线索，并更好地了解OSA与心血管疾病之间潜在的病理生理关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cardiology 医学-心血管系统

CiteScore

4.20

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Cardiology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With fourteen disciplines published across the year – including arrhythmias, molecular genetics, HDL cholesterol and clinical trials – every issue also contains annotated reference detailing the merits of the most important papers.