Influence of Pulsatility and Inflow Waveforms on Tracheal Airflow Dynamics in Healthy Older Adults.

IF 1.7 4区 医学 Q4 BIOPHYSICS
Bipin Tiwari, Abdullah Y Usmani, Sandeep Bodduluri, Surya P Bhatt, Vrishank Raghav
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Abstract

Tracheal collapsibility is a dynamic process altering local airflow dynamics. Patient-specific simulation is a powerful technique to explore the physiological and pathological characteristics of human airways. One of the key considerations in implementing airway computations is choosing the right inlet boundary conditions that can act as a surrogate model for understanding realistic airflow simulations. To this end, we numerically examine airflow patterns under the influence of different profiles, i.e., flat, parabolic, and Womersley, and compare these with a realistic inlet obtained from experiments. Simulations are performed in ten patient-specific cases with normal and rapid breathing rates during the inhalation phase of the respiration cycle. At normal breathing, velocity and vorticity contours reveal primary flow structures on the sagittal plane that impart strength to cross-plane vortices. Rapid breathing, however, encounters small recirculation zones. Quantitative flow metrics are evaluated using time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI). Overall, the flow metrics encountered in a real velocity profile are in close agreement with parabolic and Womersley profiles for normal conditions, however, the Womersley inlet alone conforms to a realistic profile under rapid breathing conditions.

脉动和流入波形对健康老年人气管气流动力学的影响。
气管塌陷是一个改变局部气流动力学的动态过程。针对患者的模拟是探索人类气道生理和病理特征的强大技术。实现气道计算的关键考虑因素之一是选择正确的入口边界条件,该条件可以作为理解真实气流模拟的替代模型。为此,我们对不同剖面(即平面、抛物线和Womersley)影响下的气流模式进行了数值研究,并将其与实验中获得的真实入口进行了比较。在呼吸周期的吸入阶段,对10个呼吸频率正常和快速的患者特定病例进行模拟。在正常呼吸时,速度和涡度等值线显示了矢状面上的主要流动结构,这些结构赋予了跨平面涡流强度。然而,快速呼吸会遇到小的再循环区。使用时间平均壁剪切应力(TAWSS)和振荡剪切指数(OSI)来评估定量流量指标。总的来说,真实速度剖面中遇到的流量指标与正常条件下的抛物线和沃默斯利剖面非常一致,然而,沃默斯利入口单独符合快速呼吸条件下的真实剖面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.40
自引率
5.90%
发文量
169
审稿时长
4-8 weeks
期刊介绍: Artificial Organs and Prostheses; Bioinstrumentation and Measurements; Bioheat Transfer; Biomaterials; Biomechanics; Bioprocess Engineering; Cellular Mechanics; Design and Control of Biological Systems; Physiological Systems.
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