Reflections on the Applications of Immunohistochemistry to Understanding the Maintenance of Electrochemical Gradients in the Inner Ear.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-01 Epub Date: 2023-08-03 DOI:10.1369/00221554231190438

Bradley A Schulte

引用次数: 0

Abstract

The author of the accompanying classic paper from the Journal of Histochemistry and Cytochemistry (Crouch JJ, Sakaguchi N, Lytle C, Schulte BA. Immunohistochemical localization of the Na-K-Cl Co-transporter (NKCC1) in the Gerbil Inner Ear. Journal of Histochemistry & Cytochemistry 1997;45(6):773-778) comments on how the immunohistochemical techniques used in the study provided critical new information that helped define the cellular and molecular mechanisms involved in the generation and maintenance of electrochemical gradients in the ear, particularly the presence of the Na,K,2Cl symporter (NKCC) in the inner ear. (J Histochem Cytochem 71: 509-510, 2023).

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应用免疫组织化学方法研究内耳电化学梯度的维持。

《组织化学与细胞化学杂志》随附经典论文的作者（Crouch JJ，Sakaguchi N，Lytle C，Schulte BA。Gerbil内耳中Na-K-Cl-Co转运蛋白（NKCC1）的免疫组织化学定位。组织化学与细胞化学杂志1997；45（6）:773-778）评论了研究中使用的免疫组织化学技术如何提供关键的新信息，这些信息有助于确定耳朵中电化学梯度的产生和维持所涉及的细胞和分子机制，特别是内耳中Na，K，2Cl转运体（NKCC）的存在。（J Histochem Cytochem 71:509-5102023）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.