下载PDF
{"title":"Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development.","authors":"Xuanhong Jin, Liangkun You, Jincheng Qiao, Weidong Han, Hongming Pan","doi":"10.1080/15548627.2023.2259214","DOIUrl":null,"url":null,"abstract":"<p><strong>Abbreviations: </strong>A. muciniphila: Akkermansia muciniphila; AIEC: adherent invasive Escherichia coli; AOM/DSS: azoxymethane-dextran sodium sulfate; ATG: autophagy related; BECN1: beclin1, autophagy related; CAC: colitis-associated colon cancer; CCDC50: coiled-coil domain containing 50; CLDN2: claudin 2; CoPEC: colibactin-producing Escherichia coli; CRC: colorectal cancer; DAMPs: danger/damage-associated molecular patterns; DC: dendritic cell; DSS: dextran sulfate sodium; DTP: drug-resistant persistent; ER: endoplasmic reticulum; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; IBD: inflammatory bowel disease; IECs: intestinal epithelial cells; IKK: IkappaB kinase; IL: interleukin; IRGM1: immunity-related GTPase family M member 1; ISC: intestinal stem cell; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAPK: mitogen-activated protein kinase; MDP: muramyl dipeptide; MELK: maternal embryonic leucine zipper kinase; MHC: major histocompatibility complex; miRNA: microRNA; MTOR: mechanistic target of rapamycin kinase; NLRP3: NLR family, pyrin domain containing 3; NOD2: nucleotide-binding oligomerization domain containing 2; NRBF2: nuclear receptor binding factor 2; PAMPs: pathogen-associated molecular patterns; PI3K: class I phosphoinositide 3-kinase; PtdIns3K: class III phosphatidylinositol 3-kinase; PYCARD/ASC: PYD and CARD domain containing; RALGAPA2/RalGAPα2: Ral GTPase activating protein protein, alpha subunit 2 (catalytic); RIPK2/CARD3: receptor (TNFRSF)-interacting serine-threonine kinase 2; RIPK3: receptor-interacting serine-threonine kinase 3; ROS: reactive oxygen species; sCRC: sporadic colorectal cancer; SMARCA4/BRG1: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SQSTM1: sequestosome 1; STAT3: signal transducer and activator of transcription 3; TNF/TNFA: tumor necrosis factor; ULK1: unc-51 like autophagy activating kinase 1; UPR: unfolded protein response; WT: wild-type.</p>","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":14.6000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10813649/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autophagy","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/15548627.2023.2259214","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/25 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
引用
批量引用
Abstract
Abbreviations: A. muciniphila: Akkermansia muciniphila; AIEC: adherent invasive Escherichia coli; AOM/DSS: azoxymethane-dextran sodium sulfate; ATG: autophagy related; BECN1: beclin1, autophagy related; CAC: colitis-associated colon cancer; CCDC50: coiled-coil domain containing 50; CLDN2: claudin 2; CoPEC: colibactin-producing Escherichia coli; CRC: colorectal cancer; DAMPs: danger/damage-associated molecular patterns; DC: dendritic cell; DSS: dextran sulfate sodium; DTP: drug-resistant persistent; ER: endoplasmic reticulum; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; IBD: inflammatory bowel disease; IECs: intestinal epithelial cells; IKK: IkappaB kinase; IL: interleukin; IRGM1: immunity-related GTPase family M member 1; ISC: intestinal stem cell; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAPK: mitogen-activated protein kinase; MDP: muramyl dipeptide; MELK: maternal embryonic leucine zipper kinase; MHC: major histocompatibility complex; miRNA: microRNA; MTOR: mechanistic target of rapamycin kinase; NLRP3: NLR family, pyrin domain containing 3; NOD2: nucleotide-binding oligomerization domain containing 2; NRBF2: nuclear receptor binding factor 2; PAMPs: pathogen-associated molecular patterns; PI3K: class I phosphoinositide 3-kinase; PtdIns3K: class III phosphatidylinositol 3-kinase; PYCARD/ASC: PYD and CARD domain containing; RALGAPA2/RalGAPα2: Ral GTPase activating protein protein, alpha subunit 2 (catalytic); RIPK2/CARD3: receptor (TNFRSF)-interacting serine-threonine kinase 2; RIPK3: receptor-interacting serine-threonine kinase 3; ROS: reactive oxygen species; sCRC: sporadic colorectal cancer; SMARCA4/BRG1: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SQSTM1: sequestosome 1; STAT3: signal transducer and activator of transcription 3; TNF/TNFA: tumor necrosis factor; ULK1: unc-51 like autophagy activating kinase 1; UPR: unfolded protein response; WT: wild-type.
大肠杆菌相关结肠癌癌症中的自噬:探讨其在减少IBD相关CAC发生和预防中的潜在作用。
缩写:A.muciniphila:Akkermansia muciniphilla;AIEC:粘附性侵袭性大肠杆菌;AOM/DSS:偶氮甲烷葡聚糖硫酸钠;ATG:自噬相关;BECN1:beclin1,自噬相关;CAC:大肠杆菌相关结肠癌;CCDC50:包含50的线圈域;CLDN2:claudin 2;CoPEC:产大肠杆菌素的大肠杆菌;结直肠癌:癌症;DAMP:与危险/损害相关的分子模式;DC:树突状细胞;DSS:葡聚糖硫酸钠;DTP:耐药持久性;ER:内质网;ERN1/IRE1α:内质网-细胞核信号传导1;IBD:炎症性肠病;IECs:肠上皮细胞;IKK:IkappaB激酶;IL:白细胞介素;IRGM1:免疫相关GTP酶家族M成员1;ISC:肠干细胞;LPS:脂多糖;MAP1LC3/LC3:微管相关蛋白1轻链3;MAPK:丝裂原活化蛋白激酶;MDP:壁酰二肽;MELK:母体胚胎亮氨酸拉链激酶;MHC:主要组织相容性复合体;miRNA:微小RNA;MTOR:雷帕霉素激酶的机制靶点;NLRP3:NLR家族,pyrin结构域包含3个;NOD2:包含2的核苷酸结合寡聚化结构域;NRBF2:核受体结合因子2;PAMPs:病原体相关分子模式;PI3K:I类磷酸肌醇3-激酶;PtdIns3K:III类磷脂酰肌醇3-激酶;PYCARD/ASC:包含PYD和CARD域;RALGAPA2/RalGAPα2:Ral GTP酶激活蛋白,α亚基2(催化);RIPK2/CARD3:受体(TNFRSF)相互作用的丝氨酸-苏氨酸激酶2;RIPK3:受体相互作用丝氨酸-苏氨酸激酶3;ROS:活性氧;sCRC:散发性癌症;SMARCA4/BRG1:SWI/SNF相关,基质相关,染色质肌动蛋白依赖性调节因子,亚家族a,成员4;SQSTM1:螯合体1;STAT3:信号转导子和转录激活子3;TNF/TNFA:肿瘤坏死因子;ULK1:unc-51样自噬激活激酶1;UPR:未折叠蛋白反应;野生型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。