Transposable elements: McClintock’s legacy revisited

IF 39.1 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2023-09-18 DOI:10.1038/s41576-023-00652-3

Cédric Feschotte

引用次数: 0

Abstract

In 1983, Barbara McClintock was awarded the Nobel Prize in Physiology or Medicine for her discovery of transposable elements. This discovery was rooted in meticulous work on maize mutants that she had carried out 40 years earlier. Over this time frame, our perception of transposable elements has undergone important paradigm shifts, with profound implications for our understanding of genome function and evolution. In commemoration of this milestone, I revisit the legacy of this iconic scientist through the kaleidoscopic history of genetics and reflect on her achievements and the hurdles she faced in her career. Commemorating the 40th anniversary of Barbara McClintock’s Nobel Prize in Physiology or Medicine for her discovery of transposable elements, Cédric Feschotte reflects on McClintock’s life and legacy and how her work has shaped and defined the field of genetics.

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可转换元素：重新审视麦克林托克的遗产。

1983年，Barbara McClintock因发现转座元件而获得诺贝尔生理学或医学奖。这一发现源于她40年前对玉米突变体进行的细致研究。在这段时间里，我们对转座元件的感知发生了重要的范式转变，对我们理解基因组功能和进化产生了深远的影响。为了纪念这一里程碑，我回顾了这位标志性科学家在遗传学万花筒般的历史中留下的遗产，并反思了她的成就和她在职业生涯中面临的障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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