Exploring the Role of Vitamin D and the Gut Microbiome: A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and Healthy Controls.

IF 1.9 4区 医学 Q2 NURSING
Biological research for nursing Pub Date : 2023-07-01 Epub Date: 2023-01-09 DOI:10.1177/10998004221150395
Sarah W Matthews, Anna Plantinga, Robert Burr, Kevin C Cain, Tor Savidge, Kendra Kamp, Margaret M Heitkemper
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引用次数: 0

Abstract

Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction with multifaceted pathophysiology. Prior studies have demonstrated higher rates of vitamin D deficiency in individuals with IBS compared to healthy controls (HC), as well as associations of vitamin D concentration with IBS symptoms. A systematic review of 10 mouse and 14 human studies reported a positive association between vitamin D (serum levels and supplementation) and beta diversity of gut microbiome in a variety of conditions. The present retrospective case-control study aimed to compare vitamin D (25(OH)D) plasma concentrations and gut microbiome composition in adult women with IBS (n=99) and HC (n=62). Plasma concentrations of 25(OH)D were assessed using the Endocrine Society Guidelines definition of vitamin D deficiency (25(OH)D <20 ng/ml) and insufficiency (25(OH)D >20-<30 ng/ml). 16S rRNA microbiome gene sequencing data was available for 39 HC and 62 participants with IBS. Genus-level Bifidobacterium and Lactobacillus and phylum-level Firmicutes and Bacteroidetes relative abundances were extracted from microbiome profiles. Results showed vitamin D deficiency in 40.3% (n=25) vs. 41.4% (n=41), and insufficiency 33.9% (n=21) vs. 34.3% (n=34) in the HCs vs. IBS groups, respectively. The odds of IBS did not differ depending on 25(OH)D status (p=0.75 for deficient, p=0.78 for insufficient), and the average plasma vitamin D concentration did not differ between IBS (mean 24.8 ng/ml) and HCs (mean 25.1 ng/ml; p=0.57). We did not find evidence of an association between plasma 25(OH)D concentration and richness, Shannon index, Simpson index or specific bacterial abundances in either HCs or the IBS group.

探索维生素 D 和肠道微生物组的作用:肠易激综合征患者与健康对照组的横断面研究》(A Cross-Sectional Study of Individuals with Irritable Bowel Syndrome and Healthy Controls)。
肠易激综合征(IBS)是一种常见的肠道与大脑相互作用的疾病,其病理生理学具有多面性。先前的研究表明,与健康对照组(HC)相比,肠易激综合征患者的维生素 D 缺乏率更高,维生素 D 浓度与肠易激综合征症状也有关联。一项对 10 项小鼠研究和 14 项人类研究的系统性回顾报告称,在各种情况下,维生素 D(血清水平和补充剂)与肠道微生物组的 beta 多样性之间存在正相关。本回顾性病例对照研究旨在比较患有肠易激综合征的成年女性(人数=99)和患有肠易激综合征的成年女性(人数=62)的维生素 D(25(OH)D)血浆浓度和肠道微生物组组成。血浆中 25(OH)D 的浓度是根据内分泌学会指南中维生素 D 缺乏的定义(25(OH)D 20-
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来源期刊
CiteScore
5.10
自引率
4.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)
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