Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae).

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-07-26 DOI:10.1515/znc-2022-0204

Vanneck Bedel Tatsinda Tsapi, Yannick Stéphane Fotsing Fongang, Angelbert Fusi Awantu, Jean Jules Kezetas Bankeu, Mehreen Lateef, Jean Rodolphe Chouna, Pépin Nkeng-Efouet-Alango, Muhammad Shaiq Ali, Bruno Ndjakou Lenta

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引用次数: 0

Abstract

Crotofoligandrin (1), a new endoperoxide crotofolane-type diterpenoid was isolated from the dichloromethane/methanol (1:1) extract of the twigs of Croton oligandrus Pierre Ex Hutch along with thirteen known secondary metabolites including 1-nonacosanol (2), lupenone (3), friedelin (4), β-sitosterol (5), taraxerol (6), (-)-hardwickiic acid (7), apigenin (8), acetyl aleuritolic acid (9), betulinic acid (10), fokihodgin C 3-acetate (11), D-mannitol (12), scopoletin (13) and quercetin (14). The structures of the isolated compounds were determined based on their spectroscopic data. The crude extract and the isolated compounds were assessed in vitro for their antioxidant, lipoxygenase, butyrylcholinesterase (BChE), urease and glucosidase inhibitory potentials. Compounds 1-3, and 10 displayed activities on all the performed bioassays. All the tested samples showed strong to significant antioxidant activity with compound 1 being the most potent (IC₅₀ 39.4 μM).

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Crotofoligandrin:从大戟科Croton oligandrus Pierre ex. Hutch树枝中提取的一种新的内过氧化物crotofolane型二萜。

从Croton oligandrus Pierre Ex Hutch嫩枝的二氯甲烷/甲醇(1:1)提取物中分离出一种新的内过氧化物Crotofoligandrin(1)，并分离出13种已知的次生代谢产物，包括1-nonacosanol(2)、lupenone(3)、friedelin(4)、β-谷甾醇(5)、taraxerol(6)、(-)-hardwickiic acid(7)、芹菜素(8)、acetyl aleuritolic acid(9)、桦木酸(10)、fokigin c3 -acetate(11)、d -甘露醇(12)、东莨菪碱(13)和槲皮素(14)。分离化合物的结构是根据它们的光谱数据确定的。对粗提物和分离物进行体外抗氧化、脂氧合酶、丁基胆碱酯酶(BChE)、脲酶和葡萄糖苷酶抑制活性测定。化合物1-3和10在所有进行的生物测定中都显示出活性。所有样品均表现出较强的抗氧化活性，其中化合物1的IC50值最高(39.4 μM)。

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来源期刊

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences 生物-生化与分子生物学

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.