Clinicopathological Risk Factors of Unfavorable Outcomes in Vietnamese Women with Primary Invasive Breast Cancer: A Retrospective Cohort Study.

IF 3.3 4区 医学 Q2 ONCOLOGY
Chau Giang Huynh, Nghiem Xuan Huynh, Bich-Ha Thi Truong, Truc Thanh Thai, Phuong-Thao Thi Doan
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Abstract

Background: The rate of unfavorable outcomes, such as recurrence and death, in women with invasive breast cancer varies widely across countries and populations. Identifying those with high-risk profiles is critical so that early detection, prediction, and intervention can be made to improve their survival rate. Therefore, our study evaluated the rate of unfavorable outcomes and its association with clinicopathological characteristics in Vietnamese women with primary invasive breast cancer.

Methods: A retrospective open cohort study was conducted on Vietnamese women with invasive breast cancer who underwent a mastectomy and were regularly followed up by the hospitals. Kaplan-Meier method was used to estimate the rate of unfavorable outcomes to take into account the follow-up time of each patient. Univariate and multiple Cox regression analyses were conducted to examine the associations between unfavorable outcomes and clinicopathological characteristics.

Results: Among 204 women included in the data analysis, the mean age was 54.4 ± 10.9 years. The majority of patients were diagnosed with early-stage (76.5%) or locally advanced (22.5%) breast cancer. The 5-year rate of unfavorable outcomes was 12.8%, and the 8-year rate was 31.7%. Patients with advanced stages had a higher risk of unfavorable outcomes compared to those with early stages (IA, IIA, T2N1). Patients with lymph node metastases and those with triple-negative molecular classification had significantly higher rates of unfavorable outcomes.

Conclusion: Although Vietnamese women with breast cancer have a relatively low rate of unfavorable outcomes compared to other countries, findings from this study emphasize the importance of early detection and underscore the need for targeted interventions for patients with advanced stages, lymph node metastases, and triple-negative breast cancer to optimize their treatment, outcomes, and overall prognosis.

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越南妇女原发性浸润性乳腺癌不良预后的临床病理危险因素:一项回顾性队列研究
背景:浸润性乳腺癌患者的不良结局发生率,如复发和死亡,在不同的国家和人群中差异很大。识别出那些具有高风险特征的人是至关重要的,这样可以进行早期发现、预测和干预,以提高他们的存活率。因此,我们的研究评估了越南原发性浸润性乳腺癌妇女的不良预后率及其与临床病理特征的关系。方法:对越南行乳房切除术的浸润性乳腺癌患者进行回顾性开放队列研究,并定期随访医院。考虑每位患者随访时间,采用Kaplan-Meier法估计不良结局发生率。进行单因素和多因素Cox回归分析,以检查不良结果与临床病理特征之间的关系。结果:纳入资料分析的204例女性中,平均年龄为54.4±10.9岁。大多数患者被诊断为早期(76.5%)或局部晚期(22.5%)乳腺癌。5年不良预后率为12.8%,8年不良预后率为31.7%。与早期患者相比,晚期患者出现不良结果的风险更高(IA, IIA, tn1)。淋巴结转移患者和三阴性分子分类患者的不良预后率明显更高。结论:尽管与其他国家相比,越南女性乳腺癌患者的不良预后率相对较低,但本研究的结果强调了早期发现的重要性,并强调了对晚期、淋巴结转移和三阴性乳腺癌患者进行有针对性干预的必要性,以优化其治疗、预后和整体预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
40
审稿时长
16 weeks
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