Fatty acid-binding protein 5 differentially impacts dopamine signaling independent of sex and environment

Addiction neuroscience Pub Date : 2023-07-07 DOI:10.1016/j.addicn.2023.100118

Brittany J. Richardson , John Hamilton , Nicole Roeder , Kyriaki Z. Thanos , Matthew Marion , Panayotis K. Thanos

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引用次数: 1

Abstract

Epidermal/brain fatty acid-binding protein 5 (FABP5) plays an integral role in the intracellular trafficking of bioactive lipids/endocannabinoids and the subsequent initiation of cellular cascades affecting cannabinoid and dopamine (DA) systems. Social isolation (SI) and environmental enrichment (EE) during adolescence have been shown to impact DA signaling, and, specifically, DA transporter (DAT) and receptor levels of DA type 1 (D1) and 2 (D2); however, the relationship between FABP5, environment and DA signaling remains unclear. The present study quantified DAT and DA receptor levels in male/female FABP5−/− and FABP5+/+ mice raised in either SI or EE. Results showed that FABP5−/− mice had 6.09–8.81% greater D1 levels in striatal sub-regions of the caudal brain, independent of sex or environment. D1 levels were 8.03% greater only in the olfactory tubercle of enrichment-reared animals. In summary, these results supported that FABP5 plays an important function in regulating striatal DA signaling, and this may have important implications as a target with therapeutic potential for various psychiatric disorders.

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脂肪酸结合蛋白5对多巴胺信号的影响与性别和环境无关

表皮/脑脂肪酸结合蛋白5（FABP5）在生物活性脂质/内源性大麻素的细胞内运输以及随后影响大麻素和多巴胺（DA）系统的细胞级联反应中发挥着不可或缺的作用。青春期的社会隔离（SI）和环境富集（EE）已被证明会影响DA信号传导，特别是DA转运体（DAT）和DA 1型（D1）和2型（D2）的受体水平；然而，FABP5、环境和DA信号之间的关系尚不清楚。本研究量化了在SI或EE中饲养的雄性/雌性FABP5−/-和FABP5+/+小鼠的DAT和DA受体水平。结果显示，无论性别或环境如何，FABP5–/-小鼠尾脑纹状体亚区的D1水平都高出6.09–8.81%。D1水平仅在富集饲养动物的嗅结节中高出8.03%。总之，这些结果支持FABP5在调节纹状体DA信号传导中发挥重要作用，这可能对作为具有治疗各种精神疾病潜力的靶点具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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