The Study of Risk Factors and The Predict Model of Cerebral Microbleeds.

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Current neurovascular research Pub Date : 2023-01-01 DOI:10.2174/1567202620666230710160809

Tao Lv, Changqing Li

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引用次数: 0

Abstract

Background: To determine the association of cardiovascular risk factors with the presence and anatomic location of CMBs and construct a factor-based evaluating model to predict a high CMBs burden.

Methods: We assessed the relation of age, male, various cardiovascular risk factors, medication use, stroke histories and white matter hyperintensities (WMH) to the presence and location of CMBs with univariate analysis and multiple logistic regression. Finally, we added risk factors for a high CMBs burden to a factor-based evaluating model score.

Results: 485 patients were included in our study. CMBs were more prevalent with advanced age, male sex, more cardiovascular risk factors and WMH. Alcohol use, hemorrhagic stroke history and the degree of deep white matter hyperintensity (DWMH) were independent predictors for a high CMBs burden (≥10). We finally structured a prediction model-HPSAD3 that consisted of hypertension, alcohol use, hemorrhagic stroke history and WMH to predict a high CMBs burden. The model-HPSAD3 has a higher positive predict value (77.08%) and negative predict value (75.89%) to predict a high CMBs burden when the cut-off score is 4.

Conclusions: Hypertension, alcohol use, hemorrhagic stroke history and WMH were added into the model- HPSAD3, and there was a higher possibility of patients with CMBs ≥10 when the score of HPSAD3 ≥4.

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脑微出血危险因素及预测模型的研究。

背景：确定心血管危险因素与CMBs的存在和解剖位置的相关性，并构建一个基于因素的评估模型来预测CMBs高负荷。方法：我们通过单因素分析和多元逻辑回归评估了年龄、男性、各种心血管危险因素、药物使用、卒中史和白质高信号（WMH）与CMBs的存在和位置的关系。最后，我们将CMB高负担的风险因素添加到基于因素的评估模型得分中。结果：485例患者纳入本研究。CMBs在高龄、男性、更多心血管危险因素和WMH中更为普遍。饮酒、出血性卒中史和深白质高信号（DWMH）程度是高CMBs负荷（≥10）的独立预测因素。我们最终构建了一个由高血压、饮酒、出血性卒中史和WMH组成的预测模型-HPSAD3，以预测高CMBs负担。当临界分数为4时，模型-HPSAD3具有较高的阳性预测值（77.08%）和阴性预测值（75.89%）来预测高CMBs负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current neurovascular research 医学-临床神经学

CiteScore

3.80

自引率

9.50%

发文量

审稿时长

3 months

期刊介绍： Current Neurovascular Research provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum publishing novel and original work as well as timely neuroscience research articles, full-length/mini reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridges the gap between basic science research and clinical discovery. Current Neurovascular Research emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.