Detection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins

IF 8.1 1区医学 Q1 CLINICAL NEUROLOGY

Annals of Neurology Pub Date : 2023-08-26 DOI:10.1002/ana.26776

Christopher M. Bartley MD, PhD, Thomas T. Ngo BS, Le Duy Do PhD, Anastasia Zekeridou MD, PhD, Ravi Dandekar BS, MS, Sergio Muñiz-Castrillo MD, PhD, Bonny D. Alvarenga BA, Kelsey C. Zorn BA, MHS, Asritha Tubati BS, Anne-Laurie Pinto MSc, Weston D. Browne BS, Patrick W. Hullett MD, PhD, Mark Terrelonge MD, MPH, Ryan D. Schubert MD, Amanda L. Piquet MD, Binxia Yang PhD, Mayra Montalvo MD, Andrew F. Kung BA, Sabrina A. Mann BS, Maulik P. Shah MD, MHS, Michael D. Geschwind MD, PhD, Jeffrey M. Gelfand MD, MAS, Joseph L. DeRisi PhD, Sean J. Pittock MD, Jérôme Honnorat MD, PhD, Samuel J. Pleasure MD, PhD, Michael R. Wilson MD, MAS

引用次数: 0

Abstract

Co‐occurring anti‐tripartite motif‐containing protein 9 and 67 autoantibodies (TRIM9/67‐IgG) have been reported in only a very few cases of paraneoplastic cerebellar syndrome. The value of these biomarkers and the most sensitive methods of TRIM9/67‐IgG detection are not known.

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检测针对TRIM9和TRIM67蛋白质的高风险副肿瘤抗体。

目的：仅在极少数副肿瘤性小脑综合征病例中报道了同时存在的含有蛋白9和67自身抗体（TRIM9/67IgG）的抗三重基序。这些生物标志物的价值和TRIM9/67 IgG检测的最敏感方法尚不清楚。方法：我们进行了一项回顾性多中心研究，通过组织免疫荧光、肽-噬菌体显示免疫沉淀测序、过表达细胞分析（CBA）和免疫印迹来评估候选TRIM9/67 IgG病例的脑脊液和血清。其中TRIM9/67 IgG通过至少2次测定检测到的病例被认为是TRIM9/67IgG阳性。结果：在这些病例中（n = 13），CBA是最敏感的（100%），并显示所有病例都具有TRIM9和TRIM67自身抗体。在有临床病史的TRIM9/67 IgG病例中，亚急性小脑综合征是最常见的表现（n = 7/10），然后是脑炎（n = 3/10）。在这10名患者中，70%患有癌症共病（7/10），其中85%（n = 6/7）证实有转移性疾病。所有可评估的癌症活组织检查均表达TRIM9蛋白（n = 5/5），其在组织的癌性区域中的表达在5例中的4例中升高。解释：TRIM9/67 IgG是一种罕见但可能高风险的副肿瘤生物标志物，CBA似乎是最敏感的诊断方法。ANN NEUROL 2023。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.