COVID-19 infection in people living with HIV.

IF 6.7 2区医学 Q1 Medicine

British medical bulletin Pub Date : 2023-09-12 DOI:10.1093/bmb/ldac031

Jacob Brolly, David R Chadwick

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引用次数: 0

Abstract

Background: Coronavirus disease 2019 (COVID-19) and human immunodeficiency virus (HIV) are intersecting pandemics, with implications for care at an individual and global scale.

Sources of data: PubMed search with relevant articles and their references reviewed.

Areas of agreement: COVID-19 has changed the delivery of care to people living with HIV (PLWH). Vaccines are efficacious and safe for PLWH; patient care for symptomatic COVID-19 is similar to that of people without HIV.

Areas of controversy: It remains unclear whether PLWH experience increased COVID-19-specific mortality. Treatments to reduce severity in early COVID-19 infection lack evidence in PLWH.

Growing points: The effects of the COVID-19 pandemic on HIV-related morbidity and mortality are yet to be seen. COVID-19 epidemiology among PLWH is complicated by changes to the severe acute respiratory syndrome coronavirus 2, population behaviours and vaccine availability.

Areas timely for developing research: Global trends in HIV-related morbidity and mortality should be monitored to appreciate the effects of the COVID-19 pandemic. The benefits of early antiviral and/or neutralizing monoclonal antibody (nMAb) treatment for PLWH and nMAb prophylaxis require investigation.

查看原文本刊更多论文

艾滋病毒感染者感染新冠肺炎。

背景：2019冠状病毒病（新冠肺炎）和人类免疫缺陷病毒（HIV）是交叉的流行病，对个人和全球范围的护理有影响。数据来源：PubMed检索相关文章及其参考文献。协议领域：新冠肺炎改变了向艾滋病毒感染者（PLWH）提供护理的方式。疫苗对PLWH有效且安全；有症状的新冠肺炎患者的护理与无艾滋病毒患者的护理相似。争议领域：目前尚不清楚PLWH是否经历了新冠肺炎特异性死亡率的增加。降低早期新冠肺炎感染严重程度的治疗方法在PLWH中缺乏证据。增长点：新冠肺炎大流行对HIV相关发病率和死亡率的影响尚待观察。PLWH中的新冠肺炎流行病学因严重急性呼吸综合征冠状病毒2、人群行为和疫苗可用性的变化而变得复杂。及时开展研究的领域：应监测艾滋病毒相关发病率和死亡率的全球趋势，以了解新冠肺炎大流行的影响。早期抗病毒和/或中和单克隆抗体（nMAb）治疗对PLWH和nMAb预防的益处需要研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British medical bulletin 医学-医学：内科

CiteScore

13.10

自引率

1.50%

发文量

审稿时长

>12 weeks

期刊介绍： British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries. Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.