Osteoarthritis models: From animals to tissue engineering.

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING
Hongyuan Dou, Shuhan Wang, Jiawei Hu, Jian Song, Chao Zhang, Jiali Wang, Lin Xiao
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引用次数: 1

Abstract

Osteoarthritis (OA) is a chronic degenerative osteoarthropathy. Although it has been revealed that a variety of factors can cause or aggravate the symptoms of OA, the pathogenic mechanisms of OA remain unknown. Reliable OA models that accurately reflect human OA disease are crucial for studies on the pathogenic mechanism of OA and therapeutic drug evaluation. This review first demonstrated the importance of OA models by briefly introducing the OA pathological features and the current limitations in the pathogenesis and treatment of OA. Then, it mainly discusses the development of different OA models, including animal and engineered models, highlighting their advantages and disadvantages from the perspective of pathogenesis and pathology analysis. In particular, the state-of-the-art engineered models and their potential were emphasized, as they may represent the future direction in the development of OA models. Finally, the challenges in obtaining reliable OA models are also discussed, and possible future directions are outlined to shed some light on this area.

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Abstract Image

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骨关节炎模型:从动物到组织工程。
骨关节炎(OA)是一种慢性退行性骨关节病。虽然已经发现多种因素可引起或加重OA的症状,但OA的发病机制尚不清楚。准确反映人类OA疾病的可靠OA模型对于OA发病机制研究和治疗药物评价至关重要。本文首先通过简要介绍骨关节炎的病理特征以及目前在骨关节炎发病机制和治疗方面的局限性,说明骨关节炎模型的重要性。然后,主要讨论了不同OA模型的发展,包括动物模型和工程模型,从发病机制和病理分析的角度,突出了它们的优缺点。特别强调了最先进的工程模型及其潜力,因为它们可能代表OA模型发展的未来方向。最后,还讨论了获得可靠OA模型的挑战,并概述了可能的未来方向,以阐明这一领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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