The Presence of Residual Vascular and Adipose Tissue Inflammation on ¹⁸F-FDG PET in Patients with Chronic Coronary Artery Disease.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine and Molecular Imaging Pub Date : 2023-06-01 DOI:10.1007/s13139-022-00785-z

Sini Toivonen, Miia Lehtinen, Peter Raivio, Juha Sinisalo, Antti Loimaala, Valtteri Uusitalo

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Abstract

Purpose: We evaluated the residual vascular and adipose tissue inflammation in patients with chronic coronary artery disease (CAD) using positron emission tomography (PET).

Methods: Our study population consisted of 98 patients with known CAD and 94 control subjects who had undergone ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET due to non-cardiac reasons. Aortic root and vena cava superior ¹⁸F-FDG uptake were measured to obtain the aortic root target-to-background ratio (TBR). In addition, adipose tissue PET measurements were done in pericoronary, epicardial, subcutaneous, and thoracic adipose tissue. Adipose tissue TBR was calculated using the left atrium as a reference region. Data are presented as mean ± standard deviation or as median (interquartile range).

Results: The aortic root TBR was higher in CAD patients compared to control subjects, 1.68 (1.55-1.81) vs. 1.53 (1.43-1.64), p < 0.001. Subcutaneous adipose tissue uptake was elevated in CAD patients 0.30 (0.24-0.35) vs. 0.27 (0.23-0.31), p < 0.001. Metabolic activity of CAD patients and control subjects was comparable in the pericoronary (0.81 ± 0.18 vs. 0.80 ± 0.16, p = 0.59), epicardial (0.53 ± 0.21 vs. 0.51 ± 0.18, p = 0.38) and thoracic (0.31 ± 0.12 vs. 0.28 ± 0.12, p = 0.21) adipose tissue regions. Aortic root or adipose tissue ¹⁸F-FDG uptake was not associated with the common CAD risk factors, coronary calcium score, or aortic calcium score (p value > 0.05).

Conclusion: Patients with a chronic CAD had a higher aortic root and subcutaneous adipose tissue ¹⁸F-FDG uptake compared to control patients, which suggests residual inflammatory risk.

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慢性冠状动脉疾病患者18F-FDG PET显示残留血管和脂肪组织炎症的存在

目的:利用正电子发射断层扫描(PET)评价慢性冠状动脉疾病(CAD)患者血管和脂肪组织的残余炎症。方法:我们的研究人群包括98例已知的CAD患者和94例对照组，他们因非心脏原因接受了18f -氟脱氧葡萄糖(18F-FDG) PET。测量主动脉根部和上腔静脉18F-FDG摄取，获得主动脉根部靶本底比(TBR)。此外，还对冠状动脉周围、心外膜、皮下和胸部脂肪组织进行了脂肪组织PET测量。以左心房为参照区计算脂肪组织TBR。数据以平均值±标准差或中位数(四分位间距)表示。结果:冠心病患者主动脉根部TBR高于对照组，分别为1.68(1.55-1.81)比1.53 (1.43-1.64)，p p = 0.59)、心外膜(0.53±0.21比0.51±0.18,p = 0.38)和胸廓(0.31±0.12比0.28±0.12,p = 0.21)脂肪组织区。主动脉根部或脂肪组织18F-FDG摄取与常见CAD危险因素、冠状动脉钙评分或主动脉钙评分无关(p值> 0.05)。结论:与对照组相比，慢性冠心病患者主动脉根部和皮下脂肪组织18F-FDG摄取较高，提示存在残留炎症风险。

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来源期刊

Nuclear Medicine and Molecular Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.20

自引率

7.70%

发文量

期刊介绍： Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor. The Korean Society of Nuclear Medicine (KSNM) KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.