Increased anti-inflammatory activity and enhanced phytochemical concentrations in superfine powders obtained by controlled differential sieving process from four medicinal plants.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Rachid Soulimani, Amadou Dicko, Elie Baudelaire, Jaouad Bouayed
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引用次数: 2

Abstract

Anti-inflammatory effect of Rosa canina, Salix alba, Scrophularia nodosa and Hedera helix were studied in LPS-stimulated primary peripheral blood mononuclear cells (PBMCs) from mice (n=18) by comparing homogeneous powders of small microparticles (50-100 μm, 100-180 μm and 180-315 μm) obtained from plants via a controlled differential sieving process (CDSp) versus total plant materials obtained via hydroethanolic (HE) extraction. Further, phytochemical composition of the fine powders and HE extracts was determined by LC-PDA-ESI/MS analyses. Results showed that a one-hour pretreatment of PBMCs with fine powders, particularly those with superfine particle sizes (i.e. 50-100 μm and 100-180 μm), significantly inhibited TNFα, IL-1β, IL-6 and NO production in LPS-stimulated PBMCs, by at least ca. 20% more than HE extracts (all, p<0.05). For each of the plants studied, their superfine powdered fractions were more concentrated in phenolic contents than their HE extracts. Overall, our results further confirm CDSp, as an environmentally friendly method, for improving the concentration of bioactive compounds as well as their biological activities.

通过控制四种药用植物的差异筛分过程获得的超细粉末增加抗炎活性和植物化学物质浓度。
通过比较从植物中通过控制差筛工艺(CDSp)获得的小颗粒(50-100 μm, 100-180 μm和180-315 μm)的均匀粉末与通过氢乙醇(HE)提取的总植物材料,研究了犬玫瑰(Rosa canina)、白柳(Salix alba)、结棘棘(Scrophularia nodosa)和螺旋体(Hedera helix)在lps刺激小鼠(n=18)原代外周血单个核细胞(PBMCs)中的抗炎作用。采用LC-PDA-ESI/MS分析了细粉和HE提取物的植物化学成分。结果表明,细粉预处理1小时后,尤其是超细颗粒(50-100 μm和100-180 μm)的PBMCs,显著抑制lps刺激PBMCs中TNFα、IL-1β、IL-6和NO的产生,比HE提取物的抑制作用至少高出约20%
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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists
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