Antiviral Approaches against Influenza Virus.

IF 19 1区 医学 Q1 MICROBIOLOGY
Clinical Microbiology Reviews Pub Date : 2023-03-23 Epub Date: 2023-01-16 DOI:10.1128/cmr.00040-22
Rashmi Kumari, Suresh D Sharma, Amrita Kumar, Zachary Ende, Margarita Mishina, Yuanyuan Wang, Zackary Falls, Ram Samudrala, Jan Pohl, Paul R Knight, Suryaprakash Sambhara
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引用次数: 0

Abstract

Preventing and controlling influenza virus infection remains a global public health challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are responsible for high morbidity, mortality, and substantial economic impact. Vaccines are the prophylaxis mainstay in the fight against influenza. However, vaccination fails to confer complete protection due to inadequate vaccination coverages, vaccine shortages, and mismatches with circulating strains. Antivirals represent an important prophylactic and therapeutic measure to reduce influenza-associated morbidity and mortality, particularly in high-risk populations. Here, we review current FDA-approved influenza antivirals with their mechanisms of action, and different viral- and host-directed influenza antiviral approaches, including immunomodulatory interventions in clinical development. Furthermore, we also illustrate the potential utility of machine learning in developing next-generation antivirals against influenza.

针对流感病毒的抗病毒方法。
预防和控制流感病毒感染仍然是全球公共卫生面临的一项挑战,因为流感病毒会导致季节性流行病和意想不到的大流行病。这些感染造成了高发病率、高死亡率和巨大的经济影响。疫苗是抗击流感的主要预防手段。然而,由于疫苗接种覆盖率不足、疫苗短缺以及与流行毒株不匹配等原因,疫苗接种并不能提供完全的保护。抗病毒药物是降低流感相关发病率和死亡率的重要预防和治疗措施,尤其是在高危人群中。在此,我们回顾了目前美国食品及药物管理局批准的流感抗病毒药物及其作用机制,以及不同的病毒和宿主导向的流感抗病毒方法,包括临床开发中的免疫调节干预措施。此外,我们还说明了机器学习在开发下一代流感抗病毒药物中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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