The Case for Human Challenge Trials in COVID-19.

IF 1.8 3区哲学 Q2 ETHICS

Journal of Bioethical Inquiry Pub Date : 2024-03-01 Epub Date: 2023-09-18 DOI:10.1007/s11673-023-10309-9

George P Drewett

引用次数: 0

Abstract

The COVID-19 pandemic has necessitated rapid research to aid in the understanding of the disease and the development of novel therapeutics. One option is to conduct controlled human infection trials (CHITs). In this article I examine the history of deliberate human infection and CHITs and their utilization prior to the COVID-19 pandemic, key ethical considerations of CHITs in the COVID-19 setting, an analysis of the World Health Organization's (WHO) Key criteria for the ethical acceptability of COVID-19 human challenge studies, and a review of the two COVID-19 CHITs that have already commenced, their compliance with the WHO criteria and other ethical considerations.

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在 COVID-19 中进行人体挑战试验的案例。

由于 COVID-19 的流行，有必要开展快速研究，以帮助人们了解该疾病并开发新型疗法。一种方法是进行控制性人类感染试验（CHITs）。在本文中，我将研究蓄意人类感染和 CHIT 的历史及其在 COVID-19 大流行之前的使用情况、COVID-19 背景下 CHIT 的关键伦理考虑因素、对世界卫生组织 (WHO) 关于 COVID-19 人类挑战研究伦理可接受性的关键标准的分析、对已经开始的两项 COVID-19 CHIT 的回顾、它们是否符合 WHO 标准以及其他伦理考虑因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bioethical Inquiry 医学-医学：伦理

CiteScore

5.20

自引率

8.30%

发文量

审稿时长

>12 weeks

期刊介绍： The JBI welcomes both reports of empirical research and articles that increase theoretical understanding of medicine and health care, the health professions and the biological sciences. The JBI is also open to critical reflections on medicine and conventional bioethics, the nature of health, illness and disability, the sources of ethics, the nature of ethical communities, and possible implications of new developments in science and technology for social and cultural life and human identity. We welcome contributions from perspectives that are less commonly published in existing journals in the field and reports of empirical research studies using both qualitative and quantitative methodologies. The JBI accepts contributions from authors working in or across disciplines including – but not limited to – the following: -philosophy- bioethics- economics- social theory- law- public health and epidemiology- anthropology- psychology- feminism- gay and lesbian studies- linguistics and discourse analysis- cultural studies- disability studies- history- literature and literary studies- environmental sciences- theology and religious studies