RNA epigenetic modifications in ovarian cancer: The changes, chances, and challenges.

IF 6.4 2区生物学 Q1 CELL BIOLOGY

Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-09-01 Epub Date: 2023-02-21 DOI:10.1002/wrna.1784

Lele Ye, Xuyang Yao, Binbing Xu, Wenwen Chen, Han Lou, Xinya Tong, Su Fang, Ruanmin Zou, Yingying Hu, Zhibin Wang, Dan Xiang, Qiaoai Lin, Shiyu Feng, Xiangyang Xue, Gangqiang Guo

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引用次数: 2

Abstract

Ovarian cancer (OC) is the most common female cancer worldwide. Patients with OC have high mortality because of its complex and poorly understood pathogenesis. RNA epigenetic modifications, such as m⁶ A, m¹ A, and m⁵ C, are closely associated with the occurrence and development of OC. RNA modifications can affect the stability of mRNA transcripts, nuclear export of RNAs, translation efficiency, and decoding accuracy. However, there are few overviews that summarize the link between m⁶ A RNA modification and OC. Here, we discuss the molecular and cellular functions of different RNA modifications and how their regulation contributes to the pathogenesis of OC. By improving our understanding of the role of RNA modifications in the etiology of OC, we provide new perspectives for their use in OC diagnosis and treatment. This article is categorized under: RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease.

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卵巢癌症的RNA表观遗传修饰：变化、机会和挑战。

癌症是世界上最常见的女性癌症。OC患者的死亡率很高，因为其发病机制复杂且知之甚少。RNA表观遗传学修饰，如m6 A、m1 A和m5 C，与OC的发生和发展密切相关。RNA修饰可以影响mRNA转录物的稳定性、RNA的核输出、翻译效率和解码准确性。然而，很少有综述总结m6 A RNA修饰与OC之间的联系。在这里，我们讨论了不同RNA修饰的分子和细胞功能，以及它们的调节如何有助于OC的发病机制。通过提高我们对RNA修饰在OC病因中的作用的理解，我们为其在OC诊断和治疗中的应用提供了新的视角。这篇文章分类在：RNA加工>RNA编辑和修饰疾病与发展中的RNA>疾病中的RNA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wiley Interdisciplinary Reviews: RNA CELL BIOLOGY-

CiteScore

14.80

自引率

4.10%

发文量

审稿时长

6-12 weeks

期刊介绍： WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.

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