Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak.

IF 2.5 4区医学 Q2 PARASITOLOGY

Memorias do Instituto Oswaldo Cruz Pub Date : 2023-01-01 DOI:10.1590/0074-02760220259

Tatiana Schäffer Gregianini, Richard Steiner Salvato, Regina Bones Barcellos, Fernanda Marques Godinho, Amanda Pellenz Ruivo, Viviane Horn de Melo, Júlio Augusto Schroder, Fernanda Letícia Martiny, Erica Bortoli Möllmann, Cátia Favreto, Ludmila Fiorenzano Baethgen, Vithoria Pompermaier Ferreira, Lívia Eidt de Lima, Cláudia Fasolo Piazza, Taís Raquel Marcon Machado, Irina Marieta Becker, Raquel Rocha Ramos, Guilherme Carey Frölich, Alana Fraga Rossetti, Lucas da Cunha Almeida, Tahiana Machado Antunes Rodrigues, Isabella Tabelli Bragança, Aline Alves Scarpellini Campos, Verônica Baú Manzoni, Lais Ceschini Machado, Luisa Maria Inácio da Silva, André Luiz Sá de Oliveira, Marcelo Henrique Santos Paiva, Zenaida Marion Alves Nunes, Paula Rodrigues de Almeida, Meriane Demoliner, Juliana Schons Gularte, Mariana Soares da Silva, Micheli Filippi, Vyctoria Malayhka de Abreu Góes Pereira, Fernando Rosado Spilki, Ana Beatriz Gorini da Veiga, Gabriel Luz Wallau

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Abstract

BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.

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基孔肯雅病毒感染在巴西最南端州的特点是自我限制传播(2017-2019年)和2021年更大规模的暴发。

背景:基孔肯雅热是一种蚊媒病毒，自2014年以来一直在美洲引起大规模疫情。在巴西，已经发现了亚洲-加勒比(AC)和东中部-南非(ECSA)基因型，并在巴西几个州导致了大规模暴发。在巴西最南端的南里奥格兰德州，2016年报告了第一例病例。目的和方法:我们采用基因组测序和流行病学调查来描述2017-2021年RS中基孔肯雅热(CHIKF)负担的特征。研究发现:在此期间，我们发现与旅行相关的ECSA基因型不同谱系的引入和社区传播有关的CHIKF负担增加。主要结论:到2020年，CHIKV的传入主要与旅行有关，传播有限。然后，在2021年，与引入新的ECSA谱系相关的最大疫情发生在该州。由于大量有能力的病媒和易感人群，在不久的将来可能发生CHIKV疫情，使1100多万居民面临日益增加的感染风险。

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来源期刊

Memorias do Instituto Oswaldo Cruz 医学-寄生虫学

CiteScore

5.00

自引率

3.60%

发文量

审稿时长

3-8 weeks

期刊介绍： Memórias do Instituto Oswaldo Cruz is a journal specialized in microbes & their vectors causing human infections. This means that we accept manuscripts covering multidisciplinary approaches and findings in the basic aspects of infectious diseases, e.g. basic in research in prokariotes, eukaryotes, and/or virus. Articles must clearly show what is the main question to be answered, the hypothesis raised, and the contribution given by the study. Priority is given to manuscripts reporting novel mechanisms and general findings concerning the biology of human infectious prokariotes, eukariotes or virus. Papers reporting innovative methods for diagnostics or that advance the basic research with these infectious agents are also welcome. It is important to mention what we do not publish: veterinary infectious agents research, taxonomic analysis and re-description of species, epidemiological studies or surveys or case reports and data re-analysis. Manuscripts that fall in these cases or that are considered of low priority by the journal editorial board, will be returned to the author(s) for submission to another journal.