ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2024-01-01 DOI:10.2174/1389203724666230915123217

Manisha Saini, Varnita Anand, Aditya Sharma, Anuj Pandey, Bittianda Kuttapa Thelma, Suman Kundu

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Abstract

ARL15 is a member of the RAS superfamily of small GTPases and is associated with several metabolic traits, including increased risk of diabetes, rheumatoid arthritis and lipid metabolism disorders. The ARL15 gene encodes for an uncharacterized small GTP binding protein. Its precise role in human physiology remains unknown, but several genetic association studies have recognized different variants in this gene to be statistically associated with numerous traits and complex diseases. Here, we provided the unique features of ARL15 small G protein, its association with varied metabolic and lifestyle diseases, its function in vesicular and lipid trafficking, and its binding partners. We outlined this protein as a promising and emerging therapeutic target to combat metabolic disorders like cardiovascular diseases, diabetes and rheumatoid arthritis. The review provides a comprehensive description of the current advancements in ARL15 research with a perspective that focused research will position this small GTPase as a viable target for the treatment of rheumatoid arthritis.

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ARL15 及其与多种疾病的关联：新功能和潜在治疗应用

ARL15 是小 GTP 酶 RAS 超家族的成员，与多种代谢特征有关，包括糖尿病、类风湿性关节炎和脂质代谢紊乱风险的增加。ARL15 基因编码一种未定性的小 GTP 结合蛋白。它在人类生理学中的确切作用尚不清楚，但几项遗传关联研究已确认该基因的不同变异与许多性状和复杂疾病有统计学关联。在此，我们介绍了 ARL15 小 G 蛋白的独特特征、它与各种代谢疾病和生活方式疾病的关联、它在囊泡和脂质贩运中的功能及其结合伙伴。我们概述了该蛋白是一种很有前景的新兴治疗靶点，可用于防治心血管疾病、糖尿病和类风湿性关节炎等代谢性疾病。这篇综述全面介绍了 ARL15 研究的最新进展，并指出重点研究将使这种小 GTPase 成为治疗类风湿性关节炎的可行靶点。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.