Clinicoradiological Factors Predicting Lymph Node Metastasis in Patients with Nonfunctioning Pancreatic Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis.

IF 3.2 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2023-09-13 DOI:10.1159/000534029

Boryeong Jeong, Subin Heo, Dong Wook Kim, Kyung Won Kim

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引用次数: 0

Abstract

Introduction: Lymph node metastasis of nonfunctioning pancreatic neuroendocrine neoplasms (pNENs) potentially leads to poor survival. Given the contradictory results in the literature regarding factors associated with lymph node metastasis of nonfunctioning pNENs, we conducted a systematic review and meta-analysis to determine the preoperative predictors of lymph node metastasis.

Methods: Original studies reporting factors associated with lymph node metastasis in patients with nonfunctioning pNENs were identified in PubMed, EMBASE, and Cochrane Library databases, and data from eligible studies were analyzed using random-effects meta-analysis to obtain pooled estimates of odds ratios (ORs) and their 95% confidence intervals (CIs).

Results: Eleven studies were included. Tumor size (>2 cm or >2.5 cm; OR, 5.80 [95% CI, 4.07-8.25]) and pancreatic head location (OR, 1.75 [95% CI, 1.05-2.94]) were significant preoperative predictors of lymph node metastasis. Old age (OR, 1.07 [95% CI, 0.68-1.68]) and male sex (OR, 1.12 [95% CI, 0.74-1.70]) were not significantly associated with lymph node metastasis.

Conclusions: A large tumor size and pancreatic head location can be useful for planning optimal treatment in patients with nonfunctioning pNENs.

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预测无功能性胰腺神经内分泌肿瘤患者淋巴结转移的临床放射学因素：系统回顾与元分析》。

导言：无功能性胰腺神经内分泌肿瘤（pNENs）的淋巴结转移可能导致患者生存率低下。鉴于文献中关于无功能胰腺神经内分泌瘤淋巴结转移相关因素的研究结果相互矛盾，我们进行了一项系统综述和荟萃分析，以确定淋巴结转移的术前预测因素：方法：我们在PubMed、EMBASE和Cochrane图书馆数据库中找到了报告无功能pNENs患者淋巴结转移相关因素的原始研究，并使用随机效应荟萃分析法对符合条件的研究数据进行分析，以获得几率比（OR）及其95%置信区间（CI）的汇总估计值：结果：共纳入 11 项研究。肿瘤大小（>2 厘米或>2.5 厘米；OR，5.80 [95% CI，4.07-8.25]）和胰头位置（OR，1.75 [95% CI，1.05-2.94]）是术前淋巴结转移的重要预测因素。老年（OR，1.07 [95% CI，0.68-1.68]）和男性（OR，1.12 [95% CI，0.74-1.70]）与淋巴结转移无明显相关性：结论：肿瘤体积大和胰头位置有助于规划无功能 pNEN 患者的最佳治疗方案。

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来源期刊

Neuroendocrinology 医学-内分泌学与代谢

CiteScore

8.30

自引率

2.40%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroendocrinology'' publishes papers reporting original research in basic and clinical neuroendocrinology. The journal explores the complex interactions between neuronal networks and endocrine glands (in some instances also immunecells) in both central and peripheral nervous systems. Original contributions cover all aspects of the field, from molecular and cellular neuroendocrinology, physiology, pharmacology, and the neuroanatomy of neuroendocrine systems to neuroendocrine correlates of behaviour, clinical neuroendocrinology and neuroendocrine cancers. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research, and special focus editions of topical interest.