Nida Zahid, Syed Ather Enam, Faiza Urooj, Russell Seth Martins, Thomas Mårtensson, Andreas Mårtensson, Naureen Mushtaq, Faiza Kausar, Mariya Moochhala, Muhammad Nouman Mughal, Sadaf Altaf, Salman Kirmani, Nick Brown
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引用次数: 0
Abstract
Background: Brain tumors are a common cause of morbidity, disability, cognitive deterioration and mortality in children, even after treatment. Little is know about the specific causes. The study aimed to assess potential socio-demographic and antenatal factors in primary brain tumor (PBTs) in children and young people (CYP) in Karachi, Pakistan.
Designs and methods: A single center hospital based matched case control study in Karachi, Pakistan. Cases were defined as CYP aged between 5 and 21 years with any histological type and grade of primary brain tumor of any histology, stage or grade. Data were collected from parents of 244 patients at the selected center between 2017 and 2021 via telephonic interview. Controls were 5-21 years old CYP admitted with non-oncological diagnoses matched on age and sex. Matched Odds Ratios for predictors of brain tumor in children were derived. Those of statistical significance were included in a multivariable logistic regression model.
Results: In the adjusted model, lower paternal education (matched adjusted odds ratio (maOR) 2.46; 95% CI 1.09-5.55), higher household monthly income (maOR 3.4; 95% CI 1.1-10.2), antenatal paternal use of addictive substances (maOR 19.5; 95% CI 2.1-179.8), and antenatal maternal use of analgesics during pregnancy (maOR 3.0; 95% CI 1.2-7.9) were all independently predictive of brain tumors.
Conclusion: This matched case-control study found novel associations between maternal use of analgesics, paternal use of addictive substances, higher household income, and lower paternal education and Primary Brain Tumors in Children and Young People. Longitudinal multicenter studies will be required to test these associations prospectively.
背景:脑肿瘤是儿童发病、残疾、认知能力下降和死亡的常见原因,即使在治疗后也是如此。人们对具体原因知之甚少。该研究旨在评估巴基斯坦卡拉奇儿童和年轻人(CYP)原发性脑瘤(pbt)的潜在社会人口统计学和产前因素。设计和方法:在巴基斯坦卡拉奇的一项基于单中心医院的匹配病例对照研究。病例定义为年龄在5至21岁之间,任何组织学类型和级别的原发性脑肿瘤,任何组织学,分期或级别。在2017年至2021年期间,通过电话访谈从选定中心的244名患者的父母那里收集了数据。对照组为年龄和性别匹配的非肿瘤诊断入院的5-21岁CYP。得出儿童脑肿瘤预测因子的匹配优势比。有统计学意义者纳入多变量logistic回归模型。结果:在调整后的模型中,父亲受教育程度较低(匹配调整优势比(maOR) 2.46;95% CI 1.09-5.55),较高的家庭月收入(maOR 3.4;95% CI 1.1-10.2),产前父亲使用成瘾物质(maOR 19.5;95% CI 2.1-179.8),以及产前产妇在妊娠期间使用镇痛药的情况(maOR 3.0;95% CI 1.2-7.9)均独立预测脑肿瘤。结论:这项配对病例对照研究发现,母亲使用镇痛药、父亲使用成瘾物质、较高的家庭收入和较低的父亲受教育程度与儿童和青少年原发性脑肿瘤之间存在新的关联。需要纵向多中心研究来前瞻性地检验这些关联。
期刊介绍:
The Journal of Public Health Research (JPHR) is an online Open Access, peer-reviewed journal in the field of public health science. The aim of the journal is to stimulate debate and dissemination of knowledge in the public health field in order to improve efficacy, effectiveness and efficiency of public health interventions to improve health outcomes of populations. This aim can only be achieved by adopting a global and multidisciplinary approach. The Journal of Public Health Research publishes contributions from both the “traditional'' disciplines of public health, including hygiene, epidemiology, health education, environmental health, occupational health, health policy, hospital management, health economics, law and ethics as well as from the area of new health care fields including social science, communication science, eHealth and mHealth philosophy, health technology assessment, genetics research implications, population-mental health, gender and disparity issues, global and migration-related themes. In support of this approach, JPHR strongly encourages the use of real multidisciplinary approaches and analyses in the manuscripts submitted to the journal. In addition to Original research, Systematic Review, Meta-analysis, Meta-synthesis and Perspectives and Debate articles, JPHR publishes newsworthy Brief Reports, Letters and Study Protocols related to public health and public health management activities.