Gut Microbiome Composition and Its Association with Sleep in Major Psychiatric Disorders.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2023-01-01 DOI:10.1159/000530386

Marco Mairinger, Alexander Maget, Jolana Wagner-Skacel, Sabrina Mörkl, Nina Dalkner, Teresa Hellinger, Armin Birner, Frederike T Fellendorf, Martina Platzer, Kathrin Kreuzer, Robert Queissner, Bernd Reininghaus, Melanie Lenger, Karin Fabisch, Werner Fitz, Alexandra Kohlhammer-Dohr, Alexandra Krammer, Anna Katharina Holl, Annamaria Painold, Alfred Häussl, Tatjana Maria Stross, Franziska Schmiedhofer, Adelina Tmava-Berisha, Karoline Pahsini, Sabine Marinschek, Julian Wenninger, Carlo Hamm, René Pilz, Michael Lehofer, Omid Amouzadeh-Ghadikolai, Angela Horvath, Gudrun Kainz, Birgit Gallé, Timothy G Dinan, Mary I Butler, Eva Reininghaus, Susanne Bengesser

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引用次数: 1

Abstract

Introduction: Sleep disturbances are highly prevalent across most major psychiatric disorders. Alterations in the hypothalamic-pituitary-adrenal axis, neuroimmune mechanisms, and circadian rhythm disturbances partially explain this connection. The gut microbiome is also suspected to play a role in sleep regulation, and recent studies suggest that certain probiotics, prebiotics, synbiotics, and fecal microbiome transplantation can improve sleep quality.

Methods: We aimed to assess the relationship between gut-microbiota composition, psychiatric disorders, and sleep quality in this cross-sectional, cross-disorder study. We recruited 103 participants, 63 patients with psychiatric disorders (major depressive disorder [n = 31], bipolar disorder [n = 13], psychotic disorder [n = 19]) along with 40 healthy controls. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). The fecal microbiome was analyzed using 16S rRNA sequencing, and groups were compared based on alpha and beta diversity metrics, as well as differentially abundant species and genera.

Results: A transdiagnostic decrease in alpha diversity and differences in beta diversity indices were observed in psychiatric patients, compared to controls. Correlation analysis of diversity metrics and PSQI score showed no significance in the patient and control groups. However, three species, Ellagibacter isourolithinifaciens, Senegalimassilia faecalis, and uncultured Blautia sp., and two genera, Senegalimassilia and uncultured Muribaculaceae genus, were differentially abundant in psychiatric patients with good sleep quality (PSQI >8), compared to poor-sleep quality patients (PSQI ≤8).

Conclusion: In conclusion, this study raises important questions about the interconnection of the gut microbiome and sleep disturbances.

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主要精神疾病患者肠道微生物组成及其与睡眠的关系

睡眠障碍在大多数主要精神疾病中都是非常普遍的。下丘脑-垂体-肾上腺轴、神经免疫机制和昼夜节律紊乱的改变部分解释了这种联系。肠道微生物组也被怀疑在睡眠调节中发挥作用，最近的研究表明，某些益生菌、益生元、合成菌和粪便微生物组移植可以改善睡眠质量。方法:在这项横断面交叉障碍研究中，我们旨在评估肠道微生物群组成、精神疾病和睡眠质量之间的关系。我们招募了103名参与者，63名精神障碍患者(重度抑郁症[n = 31]，双相情感障碍[n = 13]，精神障碍[n = 19])以及40名健康对照。采用匹兹堡睡眠质量指数(PSQI)评估睡眠质量。采用16S rRNA测序对粪便微生物组进行分析，并根据α和β多样性指标以及差异丰富的种和属进行组间比较。结果:与对照组相比，精神病患者的α多样性和β多样性指数的跨诊断性下降。多样性指标与PSQI评分的相关性分析在患者组和对照组中均无统计学意义。然而，睡眠质量良好(PSQI >8)的精神病患者与睡眠质量差(PSQI≤8)的精神病患者相比，异尿石杆菌属、Senegalimassilia faecalis和未培养Blautia sp. 3个属和Senegalimassilia Muribaculaceae属2个属存在差异丰度。结论:总之，这项研究提出了关于肠道微生物群与睡眠障碍之间相互关系的重要问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.