Improvement of mucosal immunity by a live-attenuated SARS-CoV-2 nasal vaccine

IF 5.7 2区 医学 Q1 VIROLOGY
Jason Yeung , Tian Wang , Pei-Yong Shi
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引用次数: 0

Abstract

The effectiveness of early COVID-19 vaccines in reducing the severity of the disease has led to a focus on developing next-generation vaccines that can prevent infection and transmission of the virus. One promising approach involves the induction of mucosal immunity through nasal administration and a variety of mucosal vaccine candidates using different platforms are currently in development. Live-attenuated viruses, less pathogenic versions of SARS-CoV-2, have promising features as a mucosal vaccine platform and have the potential to induce hybrid immunity in individuals who have already received mRNA vaccines. This review discusses the potential benefits and considerations for the use of live-attenuated SARS-CoV-2 intranasal vaccines and highlights the authors' work in developing such a vaccine platform.

SARS-CoV-2减毒鼻用疫苗对黏膜免疫的改善作用
早期新冠肺炎疫苗在降低疾病严重程度方面的有效性导致人们关注开发能够预防病毒感染和传播的下一代疫苗。一种有前景的方法是通过鼻腔给药诱导粘膜免疫,目前正在开发使用不同平台的各种粘膜候选疫苗。减毒活病毒是严重急性呼吸系统综合征冠状病毒2型的低致病性版本,作为粘膜疫苗平台具有很有前景的特点,并有可能在已经接种信使核糖核酸疫苗的个体中诱导混合免疫。这篇综述讨论了使用减毒活的严重急性呼吸系统综合征冠状病毒2型鼻内疫苗的潜在益处和注意事项,并强调了作者在开发此类疫苗平台方面的工作。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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