Visual cortex repetitive transcranial magnetic stimulation (rTMS) reversing neurodevelopmental impairments in adolescents with major psychiatric disorders (MPDs): A cross-species translational study

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2023-09-18 DOI:10.1111/cns.14427

Juan Liu, Huiling Guo, Jingyu Yang, Yao Xiao, Aoling Cai, Tongtong Zhao, Fay Y. Womer, Pengfei Zhao, Junjie Zheng, Xizhe Zhang, Jie Wang, Rongxin Zhu, Fei Wang

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Abstract

Aims

Neurodevelopmental impairments are closely linked to the basis of adolescent major psychiatric disorders (MPDs). The visual cortex can regulate neuroplasticity throughout the brain during critical periods of neurodevelopment, which may provide a promising target for neuromodulation therapy. This cross-species translational study examined the effects of visual cortex repetitive transcranial magnetic stimulation (rTMS) on neurodevelopmental impairments in MPDs.

Methods

Visual cortex rTMS was performed in both adolescent methylazoxymethanol acetate (MAM) rats and patients with MPDs. Functional magnetic resonance imaging (fMRI) and brain tissue proteomic data in rats and fMRI and clinical symptom data in patients were analyzed.

Results

The regional homogeneity (ReHo) analysis of fMRI data revealed an increase in the frontal cortex and a decrease in the posterior cortex in the MAM rats, representing the abnormal neurodevelopmental pattern in MPDs. In regard to the effects of rTMS, similar neuroimaging changes, particularly reduced frontal ReHo, were found both in MAM rats and adolescent patients, suggesting that rTMS may reverse the abnormal neurodevelopmental pattern. Proteomic analysis revealed that rTMS modulated frontal synapse-associated proteins, which may be the underpinnings of rTMS efficacy. Furthermore, a positive relationship was observed between frontal ReHo and clinical symptoms after rTMS in patients.

Conclusion

Visual cortex rTMS was proven to be an effective treatment for adolescent MPDs, and the underlying neural and molecular mechanisms were uncovered. Our study provides translational evidence for therapeutics targeting the neurodevelopmental factor in MPDs.

Abstract Image

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视觉皮层重复经颅磁刺激（rTMS）逆转重性精神障碍（MPDs）青少年的神经发育障碍：一项跨物种转化研究。

目的：神经发育障碍与青少年重性精神病（MPD）的发病基础密切相关。在神经发育的关键时期，视觉皮层可以调节整个大脑的神经可塑性，这可能为神经调控疗法提供一个有前景的靶点。这项跨物种转化研究考察了视觉皮层重复经颅磁刺激（rTMS）对多发性精神障碍患者神经发育障碍的影响：方法：在青春期醋酸甲唑甲醇（MAM）大鼠和多发性硬化症患者身上进行视觉皮层经颅磁刺激。分析了大鼠的功能磁共振成像（fMRI）和脑组织蛋白质组数据，以及患者的功能磁共振成像和临床症状数据：fMRI数据的区域同质性（ReHo）分析显示，MAM大鼠的额叶皮层增加，后部皮层减少，这代表了多发性硬化症的异常神经发育模式。至于经颅磁刺激的效果，在MAM大鼠和青少年患者身上都发现了类似的神经影像学变化，尤其是额叶ReHo的减少，这表明经颅磁刺激可能会逆转异常的神经发育模式。蛋白质组分析表明，经颅磁刺激可调节额叶突触相关蛋白，这可能是经颅磁刺激疗效的基础。此外，还观察到经颅磁刺激后患者的额叶ReHo与临床症状之间存在正相关关系：结论：视觉皮层经颅磁刺激被证明是治疗青少年多发性硬化症的有效方法，并揭示了其潜在的神经和分子机制。我们的研究为针对多发性硬化症神经发育因素的疗法提供了转化证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.