Neuroprotective effect of quercetin nanoparticles: A possible prophylactic effect in cerebellar neurodegenerative disorders

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy Pub Date : 2023-10-01 DOI:10.1016/j.jchemneu.2023.102307

Nashwa Fathy Gamal El-Tahawy , Rehab Ahmed Rifaai , Entesar Ali Saber , Seham A.Abd El-Aleem , Hanaa Hassanein Mohammed

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Abstract

Memory deficit, anxiety, coordination deficit and depression are common neurological disorders attributed to aluminum (Al) buildup in the nervous system. Quercetin nanoparticles (QNPs) are a newly developed effective neuroprotectant. We aimed to investigate the potential protective and therapeutic effects of QNPs in Al induced toxicity in rat cerebellum. A rat model of Al-induced cerebellar damage was created by AlCl₃ (100 mg/kg) administration orally for 42 days. QNPs (30 mg/kg) was administered for 42-days as a prophylactic (along with AlCl₃ administration) or therapeutic for 42-days (following AlCl₃ induced cerebellar damage). Cerebellar tissues were assessed for structural and molecular changes. The results showed that Al induced profound cerebellar structural and molecular changes, including neuronal damage, astrogliosis and tyrosine hydroxylase downregulation. Prophylactic QNPs significantly reduced Al induced cerebellar neuronal degeneration. QNPs is a promising neuroprotectant that can be used in elderly and vulnerable subjects to protect against neurological deterioration. It could be a promising new line for therapeutic intervention in neurodegenerative diseases.

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槲皮素纳米颗粒的神经保护作用:对小脑神经退行性疾病的可能预防作用

记忆缺陷、焦虑、协调缺陷和抑郁是常见的神经系统疾病，归因于神经系统中铝的积聚。槲皮素纳米粒子（QNPs）是一种新开发的有效的神经保护剂。我们旨在研究QNPs对铝诱导的大鼠小脑毒性的潜在保护和治疗作用。通过口服AlCl3（100mg/kg）42天来建立Al诱导的小脑损伤的大鼠模型。QNPs（30mg/kg）作为预防性给药（与AlCl3一起给药）或治疗性给药42天（在AlCl3诱导的小脑损伤之后）。评估小脑组织的结构和分子变化。结果表明，Al诱导了小脑结构和分子的深刻变化，包括神经元损伤、星形胶质细胞增生和酪氨酸羟化酶下调。预防性QNPs显著减少Al诱导的小脑神经元变性。QNPs是一种很有前途的神经保护剂，可用于老年人和弱势受试者，以防止神经系统恶化。它可能是神经退行性疾病治疗干预的一条有前景的新路线。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of chemical neuroanatomy 医学-神经科学

CiteScore

4.50

自引率

3.60%

发文量

审稿时长

62 days

期刊介绍： The Journal of Chemical Neuroanatomy publishes scientific reports relating the functional and biochemical aspects of the nervous system with its microanatomical organization. The scope of the journal concentrates on reports which combine microanatomical, biochemical, pharmacological and behavioural approaches. Papers should offer original data correlating the morphology of the nervous system (the brain and spinal cord in particular) with its biochemistry. The Journal of Chemical Neuroanatomy is particularly interested in publishing important studies performed with up-to-date methodology utilizing sensitive chemical microassays, hybridoma technology, immunocytochemistry, in situ hybridization and receptor radioautography, to name a few examples. The Journal of Chemical Neuroanatomy is the natural vehicle for integrated studies utilizing these approaches. The articles will be selected by the editorial board and invited reviewers on the basis of their excellence and potential contribution to this field of neurosciences. Both in vivo and in vitro integrated studies in chemical neuroanatomy are appropriate subjects of interest to the journal. These studies should relate only to vertebrate species with particular emphasis on the mammalian and primate nervous systems.