Autoimmune diseases and cancers overlapping with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A systematic review.

IF 2.5 Q2 CLINICAL NEUROLOGY
Negar Molazadeh, Gauruv Bose, Itay Lotan, Michael Levy
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引用次数: 5

Abstract

Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has various similarities with AQP4-IgG-seropositive Neuromyelitis Optica Spectrum Disorder (AQP4-IgG + NMOSD) in terms of clinical presentations, magnetic resonance imaging (MRI) findings, and response to treatment. But unlike AQP4-IgG + NMOSD, which is known to coexist with various autoimmune diseases and cancers, an association of MOGAD with these conditions is less clear.

Methods: We conducted a systematic search in PubMed, Scopus, Web of Science, and Embase based on the preferred reporting items for systematic reviews and meta-analysis (PRISMA). Duplicates were removed using Mendeley 1.19.8 (USA production) and the citations were uploaded into Covidence systematic review platform for screening.

Results: The most common autoimmune disease overlapping with MOGAD was anti-N-Methyl-D-Aspartate receptor encephalitis (anti-NMDAR-EN), followed by autoimmune thyroid disorders, and the most common autoantibody was antinuclear antibody (ANA), followed by AQP4-IgG (double-positive MOG-IgG and AQP4-IgG). A few sporadic cases of cancers and MOG-IgG-associated paraneoplastic encephalomyelitis were found.

Conclusion: Unlike AQP4-IgG + NMOSD, MOGAD lacks clustering of autoimmune diseases and autoantibodies associated with systemic and organ-specific autoimmunity. Other than anti-NMDAR-EN and perhaps AQP4-IgG + NMOSD, the evidence thus far does not support the need for routine screening of overlapping autoimmunity and neoplasms in patients with MOGAD.

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与髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)重叠的自身免疫性疾病和癌症:系统综述
背景:髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)与AQP4-IgG血清阳性视神经脊髓炎谱系障碍(AQP4-IgG + NMOSD)在临床表现、磁共振成像(MRI)表现和治疗反应方面有许多相似之处。但与已知与各种自身免疫性疾病和癌症共存的AQP4-IgG + NMOSD不同,MOGAD与这些疾病的关联尚不清楚。方法:基于系统评价和meta分析的首选报告项目(PRISMA),我们在PubMed、Scopus、Web of Science和Embase中进行了系统检索。使用Mendeley 1.19.8(美国生产)删除重复,并将引文上传到covid系统评价平台进行筛选。结果:与MOGAD重叠最常见的自身免疫性疾病是抗n -甲基- d -天冬氨酸受体脑炎(抗nmdar - en),其次是自身免疫性甲状腺疾病;最常见的自身抗体是抗核抗体(ANA),其次是AQP4-IgG (MOG-IgG和AQP4-IgG双阳性)。少数散发病例发现癌症和mog - igg相关的副肿瘤脑脊髓炎。结论:与AQP4-IgG + NMOSD不同,MOGAD缺乏与全身和器官特异性自身免疫相关的自身免疫性疾病和自身抗体的聚集性。除了抗nmdar - en和AQP4-IgG + NMOSD外,迄今为止的证据并不支持在MOGAD患者中进行重叠自身免疫和肿瘤的常规筛查的必要性。
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来源期刊
CiteScore
4.70
自引率
0.00%
发文量
54
审稿时长
15 weeks
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