A retrospective, comparative, clinical study of occlusion rate of peripherally inserted central catheters fabricated of poly(vinyl alcohol)-based hydrogel composite

IF 4.2 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Materials Science: Materials in Medicine Pub Date : 2023-07-21 DOI:10.1007/s10856-023-06736-0

Joseph Bunch, Brian Hanley, Daniel Donahue

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引用次数: 0

Abstract

Thrombotic accumulation is associated with surface interactions between blood proteins and vascular access devices. Catheter occlusion results from this process, and is a costly, common, occurrence with peripherally inserted central catheters (PICCs). Hydrophilic catheter materials exhibit antithrombotic properties. This retrospective study evaluates the occurrence of catheter occlusion of PICCs constructed of a poly(vinyl alcohol)-based hydrogel composite known as hydrophilic biomaterial (HBM), compared to thermoplastic polyurethane (TPU) control devices. A total of 121 PICCs, 60 HBM and 61 TPU, were placed in patients with a clinical need and were reviewed for the occurrence of catheter occlusion. The records review found that occlusions occurred in 0/60 (0.0%) of the HBM PICCs and 13/61 (21.3%) of TPU PICCs (p = 0.001). HBM exhibits favorable qualities for vascular access, most importantly its extreme hydrophilicity. Clinically, this may be responsible for the reduction in PICC occlusions, which could improve patient outcomes.

Graphical Abstract

Abstract Image

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关于聚乙烯醇基水凝胶复合材料外周置入中心导管闭塞率的回顾性比较临床研究

血栓积聚与血液蛋白和血管通路设备之间的表面相互作用有关。导管闭塞就是这一过程的结果，外周置入中心导管（PICC）经常发生闭塞，代价高昂。亲水性导管材料具有抗血栓形成的特性。这项回顾性研究评估了由被称为亲水性生物材料（HBM）的聚乙烯醇基水凝胶复合材料制成的 PICC 与热塑性聚氨酯（TPU）控制装置相比发生导管闭塞的情况。共有 121 个 PICC（60 个 HBM 和 61 个 TPU）被植入有临床需求的患者体内，并对导管闭塞的发生情况进行了审查。记录审查发现，0/60（0.0%）的 HBM PICC 和 13/61（21.3%）的 TPU PICC 发生了闭塞（p = 0.001）。HBM 具有良好的血管通路特性，最重要的是它具有极强的亲水性。在临床上，这可能是减少 PICC 闭塞的原因，从而改善患者的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.