Immunotherapy in non-small cell lung cancer: rationale, recent advances and future perspectives.

IF 5.1 4区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Wenxin Luo, Zhoufeng Wang, Ting Zhang, Lan Yang, Jinghong Xian, Yalun Li, Weimin Li
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引用次数: 14

Abstract

Lung cancer, with non-small cell lung cancer (NSCLC) being the major type, is the second most common malignancy and the leading cause of cancer-related death globally. Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has been one of the greatest advances in recent years for the treatment of solid tumors including NSCLC. However, not all NSCLC patients experience an effective response to immunotherapy with the established selection criteria of programmed death ligand 1 (PD-L1) and tumor mutational burden (TMB). Furthermore, a considerable proportion of patients experience unconventional responses, including pseudoprogression or hyperprogressive disease (HPD), immune-related toxicities, and primary or acquired resistance during the immunotherapy process. To better understand the immune response in NSCLC and provide reference for clinical decision-making, we herein review the rationale and recent advances in using immunotherapy to treat NSCLC. Moreover, we discuss the current challenges and future strategies of this approach to improve its efficacy and safety in treating NSCLC.

Abstract Image

Abstract Image

非小细胞肺癌的免疫治疗:基本原理、最新进展和未来展望。
肺癌,以非小细胞肺癌(NSCLC)为主要类型,是全球第二大最常见的恶性肿瘤,也是癌症相关死亡的主要原因。以免疫检查点抑制剂(ICIs)为代表的免疫疗法是近年来治疗包括非小细胞肺癌在内的实体肿瘤的最大进展之一。然而,并不是所有的NSCLC患者对程序性死亡配体1 (PD-L1)和肿瘤突变负荷(TMB)的既定选择标准的免疫治疗都有有效的反应。此外,相当比例的患者在免疫治疗过程中经历了非常规的反应,包括假进展或超进展性疾病(HPD)、免疫相关毒性和原发性或获得性耐药。为了更好地了解非小细胞肺癌的免疫应答,为临床决策提供参考,我们在此综述免疫疗法治疗非小细胞肺癌的原理和最新进展。此外,我们还讨论了该方法目前面临的挑战和未来的策略,以提高其治疗非小细胞肺癌的有效性和安全性。
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来源期刊
Precision Clinical Medicine
Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
10.80
自引率
0.00%
发文量
26
审稿时长
5 weeks
期刊介绍: Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.
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