Evidence for Correlation between Novel Autoantibody against Phospholipid Named Neoself Anti-β2-GPI/HLA-DR Antibody and Complement Consumption in Infertile Patients.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
Hirotaka Matsumi
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引用次数: 0

Abstract

Impaired implantation is one of the causes of infertility. It occurs under vital inflammatory status due to immune hyperactivation. In the innate immune system, the inflammatory response to pathogenic stimuli is initiated by complement activation. Minimal vasculitis associated with complement consumption in infertile patients may be an underlying mechanism for impaired implantation. Antiphospholipid antibodies regulate the inflammatory response. Recently, a novel autoantibody (neoself antibody) against a complex of β2-GPI and HLA class II molecules (β2-GPI/HLA-DR) has been reported to be an independent autoantibody associated with aPLs. This study investigated the relationship between neoself antibodies and complement consumption in infertile patients with impaired implantation. It was found that decreased C4 levels were strongly related to the increased neoself antibody titers in the serum among those patients whose antibody titers were not as high. On the contrary, serum levels of CH50 and CRP are not correlated with them. These results suggest that neoself antibodies might indicate low-grade inflammation, which causes endometrial vasculitis in impaired implantation of infertile patients.

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新型抗磷脂自身抗体Neoself Anti-β2-GPI/HLA-DR抗体与不孕症患者补体消耗相关的证据
着床障碍是不孕的原因之一。它发生在重要的炎症状态下,由于免疫过度激活。在先天免疫系统中,对致病性刺激的炎症反应是由补体激活发起的。不孕症患者与补体消耗相关的微小血管炎可能是着床受损的潜在机制。抗磷脂抗体调节炎症反应。最近,一种针对β2-GPI和HLA II类分子复合物(β2-GPI/HLA- dr)的新型自身抗体(neoself antibody)被报道为一种与apl相关的独立自身抗体。本研究探讨了着床受损的不孕症患者自身抗体与补体消耗的关系。结果发现,在抗体滴度不高的患者中,血清中C4水平的降低与自身抗体滴度的升高密切相关。相反,血清CH50和CRP水平与此无关。这些结果表明,新自身抗体可能提示低级别炎症,导致不孕患者着床受损的子宫内膜血管炎。
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来源期刊
Obstetrics and Gynecology International
Obstetrics and Gynecology International OBSTETRICS & GYNECOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
26
审稿时长
19 weeks
期刊介绍: Obstetrics and Gynecology International is a peer-reviewed, Open Access journal that aims to provide a forum for scientists and clinical professionals working in obstetrics and gynecology. The journal publishes original research articles, review articles, and clinical studies related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, reproductive endocrinology, and sexual medicine.
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