Cell membrane-based nanomaterials for therapeutics of neurodegenerative diseases

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemistry international Pub Date : 2023-11-01 DOI:10.1016/j.neuint.2023.105612

Phuong-Trang Nguyen-Thi , Thuy Trang Nguyen , Hoang Long Phan , Thanh-Tam Ho , Toi Van Vo , Giau Van Vo

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Abstract

Central nervous system (CNS) diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), glioblastoma (GBM), and peripheral nerve injury have been documented as incurable diseases, which lead to serious impacts on human health especially prevalent in the aging population worldwide. Most of the treatment strategies fail due to low efficacy, toxicity, and poor brain penetration. Recently, advancements in nanotechnology have helped alleviate the challenges associated with the application of cell membrane-based nanomaterials against CNS diseases. In the following review, the existing types of cell membrane-based nanomaterials systems which have improved therapeutic efficacy for CNS diseases would be described. A summary of recent progress in the incorporation of nanomaterials in cell membrane-based production, separation, and analysis will be provided. Addition to, challenges relate to large-scale manufacturing of cell membrane-based nanomaterials and future clinical trial of such platforms will be discussed.

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用于神经退行性疾病治疗的细胞膜纳米材料。

阿尔茨海默病（AD）、帕金森病（PD）、胶质母细胞瘤（GBM）和外周神经损伤等中枢神经系统疾病已被记录为不治之症，对人类健康造成严重影响，尤其是在全球老龄化人群中普遍存在。大多数治疗策略由于疗效低、毒性大和脑渗透性差而失败。最近，纳米技术的进步有助于缓解与应用基于细胞膜的纳米材料对抗中枢神经系统疾病相关的挑战。在以下综述中，将描述现有类型的基于细胞膜的纳米材料系统，这些系统提高了对中枢神经系统疾病的治疗效果。将总结纳米材料在细胞膜生产、分离和分析中的最新进展。此外，还将讨论大规模制造基于细胞膜的纳米材料的挑战以及此类平台的未来临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemistry international 医学-神经科学

CiteScore

8.40

自引率

2.40%

发文量

128

审稿时长

37 days

期刊介绍： Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.