Neural distinctiveness and discriminability underlying unitization and associative memory in aging

Abstract

Previous work has suggested unitized pairs behave as a single unit and more critically, are processed neurally different than those of associative memories. The current works examines the neural differences between unitization and non-unitized memory using fMRI and multivoxel analyses. Specifically, we examined the differences across face-occupation pairings as a function of whether the pairing was viewed as a person performing the given job (unitized binding) or a person saying they knew someone who had a particular job (non-unitized binding). The results show that at encoding and retrieval, the angular gyrus can discriminate between unitized and non-unitized target trials. Additionally, during encoding, the medial temporal lobe (hippocampus and perirhinal cortex), frontal parietal regions (angular gyrus and medial frontal gyrus) and visual regions (middle occipital cortex) exhibit distinct neural patterns to recollected unitized and non-unitized targets. Furthermore, the perirhinal cortex and medial frontal gyrus show greater neural similarity within subsequently recollected unitized trials compared to non-unitized trials. We conclude that an encoding based strategy to elicit unitization can produce greater associative memory compared to non-unitized trials in older adults. Additionally, when unitized trials are subsequently recollected in the perirhinal cortex older adults show greater neural similarity within unitized trials compared to non-unitized trials.