Clinical and prognostic significance of CCPG1 in hepatocellular carcinoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-01 DOI:10.4149/gpb_2023017

Gangpu Wang, Zhiqian Liu, Qi Wang, Bingqi Liu, Jie Li

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Abstract

This study aimed to examine the clinical and prognostic significance of cell-cycle progression gene 1 (CCPG1) in hepatocellular carcinoma (HCC). We firstly analyzed CCPG1 expression in various cancers using The Cancer Genome Atlas and the Genotype-Tissue Expression project databases. The relative expression levels of CCPG1 were determined in 164 paired HCC and adjacent tissues using immunohistochemistry. The correlation between CCPG1 and clinicopathological characteristics of HCC was analyzed. Cox proportional models were used to identify the prognostic factors for overall survival (OS) and disease-free survival (DFS). The expression of CCPG1 was lower in HCC tissues than in adjacent non-tumor liver tissues. The expression of CCPG1 was significantly correlated with tumor number (p = 0.02) and tumor differentiation (p = 0.04) in HCC. Lower expression of CCPG1 in HCC patients was associated with poor OS and DFS (p < 0.01). Relative low expression of CCPG1 in HCC is significantly correlated with the poor prognosis of HCC patients after surgical resection, suggesting its possible role as a potential prognostic marker for HCC.

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CCPG1在肝癌中的临床及预后意义。

本研究旨在探讨细胞周期进展基因1 (CCPG1)在肝细胞癌(HCC)中的临床及预后意义。我们首先使用The Cancer Genome Atlas和Genotype-Tissue expression project数据库分析了CCPG1在各种癌症中的表达。采用免疫组化方法测定164例配对HCC及其邻近组织中CCPG1的相对表达水平。分析CCPG1与HCC临床病理特征的相关性。Cox比例模型用于确定总生存期(OS)和无病生存期(DFS)的预后因素。CCPG1在HCC组织中的表达低于邻近非肿瘤肝组织。CCPG1的表达与HCC中肿瘤数量(p = 0.02)和肿瘤分化(p = 0.04)显著相关。HCC患者CCPG1低表达与较差的OS和DFS相关(p < 0.01)。CCPG1在HCC中的相对低表达与HCC患者手术切除后预后不良显著相关，提示其可能作为HCC的潜在预后标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.