Clinical and prognostic significance of CCPG1 in hepatocellular carcinoma.

IF 1.3 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

General physiology and biophysics Pub Date : 2023-09-01 DOI:10.4149/gpb_2023017

Gangpu Wang, Zhiqian Liu, Qi Wang, Bingqi Liu, Jie Li

{"title":"Clinical and prognostic significance of CCPG1 in hepatocellular carcinoma.","authors":"Gangpu Wang, Zhiqian Liu, Qi Wang, Bingqi Liu, Jie Li","doi":"10.4149/gpb_2023017","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to examine the clinical and prognostic significance of cell-cycle progression gene 1 (CCPG1) in hepatocellular carcinoma (HCC). We firstly analyzed CCPG1 expression in various cancers using The Cancer Genome Atlas and the Genotype-Tissue Expression project databases. The relative expression levels of CCPG1 were determined in 164 paired HCC and adjacent tissues using immunohistochemistry. The correlation between CCPG1 and clinicopathological characteristics of HCC was analyzed. Cox proportional models were used to identify the prognostic factors for overall survival (OS) and disease-free survival (DFS). The expression of CCPG1 was lower in HCC tissues than in adjacent non-tumor liver tissues. The expression of CCPG1 was significantly correlated with tumor number (p = 0.02) and tumor differentiation (p = 0.04) in HCC. Lower expression of CCPG1 in HCC patients was associated with poor OS and DFS (p < 0.01). Relative low expression of CCPG1 in HCC is significantly correlated with the poor prognosis of HCC patients after surgical resection, suggesting its possible role as a potential prognostic marker for HCC.</p>","PeriodicalId":12514,"journal":{"name":"General physiology and biophysics","volume":"42 5","pages":"431-442"},"PeriodicalIF":1.3000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General physiology and biophysics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.4149/gpb_2023017","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

This study aimed to examine the clinical and prognostic significance of cell-cycle progression gene 1 (CCPG1) in hepatocellular carcinoma (HCC). We firstly analyzed CCPG1 expression in various cancers using The Cancer Genome Atlas and the Genotype-Tissue Expression project databases. The relative expression levels of CCPG1 were determined in 164 paired HCC and adjacent tissues using immunohistochemistry. The correlation between CCPG1 and clinicopathological characteristics of HCC was analyzed. Cox proportional models were used to identify the prognostic factors for overall survival (OS) and disease-free survival (DFS). The expression of CCPG1 was lower in HCC tissues than in adjacent non-tumor liver tissues. The expression of CCPG1 was significantly correlated with tumor number (p = 0.02) and tumor differentiation (p = 0.04) in HCC. Lower expression of CCPG1 in HCC patients was associated with poor OS and DFS (p < 0.01). Relative low expression of CCPG1 in HCC is significantly correlated with the poor prognosis of HCC patients after surgical resection, suggesting its possible role as a potential prognostic marker for HCC.

查看原文本刊更多论文

CCPG1在肝癌中的临床及预后意义。

本研究旨在探讨细胞周期进展基因1 (CCPG1)在肝细胞癌(HCC)中的临床及预后意义。我们首先使用The Cancer Genome Atlas和Genotype-Tissue expression project数据库分析了CCPG1在各种癌症中的表达。采用免疫组化方法测定164例配对HCC及其邻近组织中CCPG1的相对表达水平。分析CCPG1与HCC临床病理特征的相关性。Cox比例模型用于确定总生存期(OS)和无病生存期(DFS)的预后因素。CCPG1在HCC组织中的表达低于邻近非肿瘤肝组织。CCPG1的表达与HCC中肿瘤数量(p = 0.02)和肿瘤分化(p = 0.04)显著相关。HCC患者CCPG1低表达与较差的OS和DFS相关(p < 0.01)。CCPG1在HCC中的相对低表达与HCC患者手术切除后预后不良显著相关，提示其可能作为HCC的潜在预后标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

General physiology and biophysics 生物-生化与分子生物学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： General Physiology and Biophysics is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level and is published quarterly by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences.