Prediabetes and skeletal health.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Current Opinion in Endocrinology & Diabetes and Obesity Pub Date : 2023-08-01 Epub Date: 2023-05-29 DOI:10.1097/MED.0000000000000812

Catherine Lindsay, Albert Shieh

引用次数: 0

Abstract

Purpose of review: Type 2 diabetes mellitus (T2D) confers a greater risk of skeletal fragility and fracture. Whether prediabetes is detrimental to bone health is uncertain.

Recent findings: We summarize the current data on the associations of prediabetes with bone turnover, bone mineral density, bone quality, bone material properties and fracture risk.

Summary: In cross-sectional studies, prediabetes was associated with lower bone turnover and worse trabecular bone quality. A longitudinal analysis showed that larger increase in insulin resistance (in the absence of T2D) correlated with faster bone loss. Future research to examine the longitudinal associations of prediabetes with bone health parameters is warranted.

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糖尿病前期与骨骼健康

审查目的：2型糖尿病（T2D）会增加骨骼脆弱和骨折的风险。糖尿病前期是否会损害骨骼健康尚不确定：摘要：在横断面研究中，糖尿病前期与较低的骨转换率和较差的骨小梁质量有关。一项纵向分析表明，胰岛素抵抗的大幅增加（在无糖尿病的情况下）与骨质流失加快有关。今后有必要对糖尿病前期与骨骼健康参数的纵向关系进行研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Endocrinology & Diabetes and Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

5.80

自引率

3.10%

发文量

128

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Endocrinology, Diabetes and Obesity delivers a broad-based perspective on the most recent and exciting developments in the field from across the world. Published bimonthly and featuring twelve key topics – including androgens, gastrointestinal hormones, diabetes and the endocrine pancreas, and neuroendocrinology – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.