Berberine may provide redox homeostasis during aging in rats.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-07-26 DOI:10.1515/znc-2022-0213

Arun Kumar Yadawa, Parisha Srivastava, Akanksha Singh, Rashmi Kesherwani, Sukanya Bhoumik, Raushan Kumar, Jitendra Kumar Arya, Syed Ibrahim Rizvi

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Abstract

Aging is a natural phenomenon, which is characterised by progressive physiological changes at cellular and organ level. During aging, the defence mechanism of an organism declines over the period of time. The aim of this study was to investigate the biological efficacy of berberine in D-galactose induced aging rat models. For the study, rats were divided into four groups: Control received only vehicle, BBR received berberine orally, D-Gal received D-galactose subcutaneously and BBR + D-Gal received D-galactose and berberine simultaneously. D-galactose treatment increased the pro-oxidants such as malondialdehyde (MDA) level, protein carbonyl, plasma membrane redox system (PMRS) and advanced oxidation protein products (AOPP) in the erythrocytes or plasma. It reduced the anti-oxidant level such as reduced glutathione (GSH), ferric reducing ability of plasma (FRAP), plasma thiols, sialic acid and membrane transporters like Na⁺/K⁺ ATPase and Ca²⁺ ATPase activity in the erythrocyte membrane. Co-treatment of berberine in D-galactose induced aging rat models restored pro-oxidants and anti-oxidants in erythrocytes. Berberine also restored the activity of Na⁺/K⁺ ATPase and Ca²⁺ ATPase in the erythrocyte membrane. On the basis of these findings, we suggest that berberine treatment could attenuate erythrocyte aging in rats through stabilisation of the redox equilibrium.

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小檗碱可能在大鼠衰老过程中提供氧化还原稳态。

衰老是一种自然现象，其特征是细胞和器官水平的进行性生理变化。在衰老过程中，机体的防御机制会随着时间的推移而衰退。本研究旨在探讨小檗碱对d -半乳糖致衰老大鼠模型的生物学功效。本研究将大鼠分为四组:对照组只给药，BBR口服小檗碱，D-Gal皮下注射d -半乳糖，BBR + D-Gal同时注射d -半乳糖和小檗碱。d -半乳糖处理增加了红细胞或血浆中的促氧化剂，如丙二醛(MDA)水平、蛋白质羰基、质膜氧化还原系统(PMRS)和高级氧化蛋白产物(AOPP)。它降低了抗氧化水平，如还原性谷胱甘肽(GSH)，血浆铁还原能力(FRAP)，血浆硫醇，唾液酸和细胞膜转运蛋白如Na+/K+ atp酶和Ca2+ atp酶活性。在d -半乳糖诱导的衰老大鼠模型中，小檗碱联合治疗可恢复红细胞中的促氧化剂和抗氧化剂。小檗碱还能恢复红细胞膜Na+/K+ atp酶和Ca2+ atp酶的活性。基于这些发现，我们认为小檗碱治疗可以通过稳定氧化还原平衡来减轻大鼠红细胞衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences 生物-生化与分子生物学

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.