The relationship of peri-implant soft tissue wound healing with implant cover screw design: Cross-sectional study

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Implant Dentistry and Related Research Pub Date : 2023-09-15 DOI:10.1111/cid.13272

Zeliha Güney, Fatma Karacaoglu, Emre Barıs, K. Gökalp Gezer, M. Murat Akkaya

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引用次数: 0

Abstract

Introduction

Dental implants are frequently preferred method for oral rehabilitation all over the world. The incidence of various complications such as incorrect prosthesis, peri-implant mucositis, and peri-implantitis is high; premature loss of implants is encountered due to osteointegration process not being completed for some unexplained reasons. However, there is no study in the literature examining the nonfunctional period of implants. Closure screws of different implant companies have different designs like surface properties, and areas, where closure screws sit, are important reservoirs for microorganism colonization. Our study aims to evaluate the inflammatory response, epithelial maturation, and epithelial-connective tissue interaction around closure screws.

Methods

For this purpose, 52 implants belonging to five different implant companies were included in the study. Tissues removed over the cover screw during fitting of healing caps were used as biopsy material and for epithelial proliferation Ki-67, for epithelium-connective tissue interaction Syndecan-1, and for macrophage activation CD-68 expressions were evaluated by immunohistochemical analysis. Scanning electron microscopy (SEM) analyzes were performed to evaluate the presence of gap between the implant and the cover screw.

Results

As a result of our study, intensity of subepithelial inflammation between groups wasn't statistically different. Differences in CD-68 and Syndecan-1 levels were obtained at the lamina propria level. H score of CD-68 was statistically significantly different in epithelium (p = 0.032), and H score of Syndecan-1 was different in lamina propria (p = 0.022). There wasn't a statistically significant difference between the groups for Ki-67 (p = 0.151).

Conclusion

Our study results indicate that in addition to the implant surface morphology, the design of the closure screws is important in the inflammatory response and epithelial maturation that develops during wound healing. Although the inflammatory response is required for healing, osteointegration, and implant survival, further investigation is needed to investigate the relationship between initial neck resorption and closure screws with radiographic and microbiological examinations.

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种植体周围软组织伤口愈合与种植体盖板螺钉设计的关系：横断面研究

导言：种植牙是全世界口腔修复的首选方法。各种并发症的发生率很高，如修复体不正确、种植体周围粘膜炎和种植体周围炎；由于某些无法解释的原因，骨结合过程没有完成，导致种植体过早脱落。然而，目前还没有文献对种植体的非功能期进行研究。不同种植体公司的封闭螺钉具有不同的设计和表面特性，而封闭螺钉所在的区域是微生物定植的重要场所。我们的研究旨在评估封闭螺钉周围的炎症反应、上皮成熟以及上皮与结缔组织的相互作用。为此，我们将五家不同种植公司的 52 个种植体纳入了研究范围。在安装愈合帽时从覆盖螺钉上取下的组织作为活检材料，通过免疫组化分析评估上皮增殖 Ki-67、上皮与结缔组织相互作用 Syndecan-1 和巨噬细胞活化 CD-68 的表达。扫描电子显微镜（SEM）分析评估了种植体与覆盖螺钉之间是否存在间隙。结果我们的研究结果表明，各组间上皮下炎症的强度无统计学差异。固有层的 CD-68 和 Syndecan-1 水平存在差异。上皮细胞中 CD-68 的 H 评分差异有统计学意义（P = 0.032），固有层中 Syndecan-1 的 H 评分差异有统计学意义（P = 0.022）。Ki-67 组间差异无统计学意义（p = 0.151）。结论我们的研究结果表明，除了种植体表面形态外，封闭螺钉的设计对伤口愈合过程中出现的炎症反应和上皮成熟也很重要。虽然炎症反应是伤口愈合、骨结合和种植体存活的必要条件，但仍需进一步研究，通过放射学和微生物学检查来研究初期颈部吸收与封闭螺钉之间的关系。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.