Associations between adverse childhood experiences and substance use: A meta-analysis

IF 3.4 2区心理学 Q1 FAMILY STUDIES

Child Abuse & Neglect Pub Date : 2025-10-01 DOI:10.1016/j.chiabu.2023.106431

Jenney Zhu , Nicole Racine , Chloe Devereux , David C. Hodgins , Sheri Madigan

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引用次数: 0

Abstract

Background

Adverse childhood experiences (ACEs) can be associated with negative health outcomes such as substance use. However, extant literature assessing this association is mixed.

Objective

The present meta-analysis was conducted to obtain a pooled effect size for the association between ACEs and substance use (i.e., smoking, problematic alcohol use, heavy alcohol use, illicit drug use, and cannabis use).

Participants and setting

The present meta-analyses included 102 studies (N = 901,864), where 42.32 % of participants were male, and the mean age was 30.91 years.

Methods

Searches were conducted in MEDLINE, Embase, and PsycINFO in August 2021 and moderators were examined. Inclusion criteria included studies that measured ACEs prior to age 18 and substance use, and were published in English. All analyses were completed in Comprehensive Meta-Analysis Software, Version 3.0 (Borenstein et al., 2009).

Results

Pooled effect sizes between ACEs and smoking [OR = 1.803 (95 % CI 1.588, 2.048)], problematic alcohol use [OR = 1.812 (95 % CI 1.606, 2.044)], heavy alcohol use [OR = 1.537 (95 % CI 1.344, 1.758)], cannabis use [OR = 1.453 (95 % CI 1.184, 1.786)] and illicit drug use [OR = 1.695 (95 % CI 1.530, 1.878)] were significant. Significant moderators contribute to the understanding of the association between ACEs and substance use, and are discussed extensively.

Conclusions

ACEs confer risk for substance use and trauma-informed approaches to substance use treatment should be considered. Study limitations and implications are discussed.

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不良童年经历与物质使用之间的关系：一项荟萃分析

童年不良经历（ace）可能与不良健康结果（如药物使用）相关。然而，现有的文献评估这种联系是混合的。目的本荟萃分析旨在获得ace与物质使用（即吸烟、问题酒精使用、重度酒精使用、非法药物使用和大麻使用）之间关联的汇总效应量。本荟萃分析包括102项研究（N = 901,864），其中42.32%的参与者为男性，平均年龄为30.91岁。方法于2021年8月在MEDLINE、Embase和PsycINFO中进行检索，并对版主进行审查。纳入标准包括测量18岁之前的ace和药物使用情况的研究，并以英语发表。所有分析均在3.0版综合元分析软件（Borenstein et al., 2009）中完成。结果ace与吸烟[OR = 1.803 (95% CI 1.588, 2.048)]、酗酒[OR = 1.812 (95% CI 1.606, 2.044)]、酗酒[OR = 1.537 (95% CI 1.344, 1.758)]、大麻使用[OR = 1.453 (95% CI 1.184, 1.786)]和吸毒[OR = 1.695 (95% CI 1.530, 1.878)]之间存在显著效应。重要调节因子有助于理解ace与药物使用之间的关系，并被广泛讨论。结论sace具有药物使用风险，应考虑创伤知情的药物使用治疗方法。讨论了研究的局限性和意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Child Abuse & Neglect Multiple-

CiteScore

7.40

自引率

10.40%

发文量

397

期刊介绍： Official Publication of the International Society for Prevention of Child Abuse and Neglect. Child Abuse & Neglect The International Journal, provides an international, multidisciplinary forum on all aspects of child abuse and neglect, with special emphasis on prevention and treatment; the scope extends further to all those aspects of life which either favor or hinder child development. While contributions will primarily be from the fields of psychology, psychiatry, social work, medicine, nursing, law enforcement, legislature, education, and anthropology, the Journal encourages the concerned lay individual and child-oriented advocate organizations to contribute.