Characterization of patients with odontogenic necrotizing soft tissue infections in the head and neck area. A retrospective analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2023-09-09 DOI:10.1080/00016357.2023.2254389

Signe Undall-Behrend Hansen, Frederik Viktor Bang Jespersen, Merete Markvart, Ole Hyldegaard, Christina Caroline Plaschke, Thomas Bjarnsholt, Claus Henrik Nielsen, Simon Storgård Jensen

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引用次数: 0

Abstract

Objective: Necrotizing soft-tissue infection (NSTI) in the head and neck area may develop from odontogenic infections. The aim of this study was to characterize patients with NSTI in the head and neck with odontogenic origin in a well-defined prospectively collected cohort.

Material and methods: Patients with NSTI in the head and neck, hospitalized between 2013 and 2017 at Copenhagen University Hospital and registered in the Scandinavian INFECT database were included. Medical records of identified patients and from the INFECT database were screened for a defined set of data including the primary focus of infection, comorbidities, predisposing factors, clinical and radiographic diagnostics, course of treatment, and treatment outcome.

Results: Thirty-five patients with NSTI in the head and neck area were included in the study. A total of 54% had odontogenic origin, primarily from mandibular molars, and 94% had radiographic signs of infectious oral conditions. Overall, comorbidities were reported in 51% with cardiovascular disease being the most prevalent. In 20%, no comorbidities or predisposing conditions could be identified. The overall 30-day mortality rate was 9%.

Conclusions: More than half of NSTI cases in the head and neck region had an odontogenic origin, and special attention should be paid to infections related to mandibular molars.

查看原文本刊更多论文

头颈部牙源性坏死软组织感染患者的特征。回顾性分析。

目的：头颈部坏死性软组织感染（NSTI）可能源于牙源性感染。本研究旨在通过明确界定的前瞻性收集队列，描述头颈部源于牙源性的坏死性软组织感染患者的特征：研究纳入了 2013 年至 2017 年期间在哥本哈根大学医院住院并在斯堪的纳维亚 INFECT 数据库中登记的头颈部 NSTI 患者。对已确定患者的病历和 INFECT 数据库中的病历进行筛选，以获得一组确定的数据，包括主要感染病灶、合并症、易患因素、临床和影像学诊断、治疗过程和治疗结果：研究共纳入 35 名头颈部 NSTI 患者。54%的患者为牙源性感染，主要来自下颌磨牙，94%的患者有口腔感染性疾病的影像学表现。总体而言，51%的患者患有合并症，其中以心血管疾病最为常见。20%的患者没有发现合并症或易感疾病。30 天的总死亡率为 9%：超过一半的头颈部 NSTI 病例源于牙源性感染，应特别注意与下颌磨牙有关的感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.