Systemic aspergillosis associated with acute enterocolitis in foals

IF 2.2 4区医学 Q3 MYCOLOGY

Journal de mycologie medicale Pub Date : 2023-09-02 DOI:10.1016/j.mycmed.2023.101433

Mariana Rodrigues Trápaga , Vanice Rodrigues Poester , Mariana Andrade Mousquer , Rafaela Pinto de Souza , Leandro Américo Rafael , Josiane Bonel , Aryse Martins Melo , Angelita Gomes Reis , Renata Osorio de Faria , David A. Stevens , Carlos Eduardo Wayne Nogueira , Melissa Orzechowski Xavier

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引用次数: 0

Abstract

Aspergillosis is an uncommon disease in horses, but it can be fatal. We report two cases of systemic aspergillosis in foals that occurred in a short period in the same region of southern Brazil. In addition, a literature review of similar cases was also performed. Risk factors were attributed to an immunodepression by primary enterocolitis and corticosteroid treatment, the damage in the epithelium, and multiple antibacterial treatments, which allowed local fungal proliferation, tissue invasion and spread of infection, leading to death. Since the antemortem diagnosis of aspergillosis in foals is difficult, our report alerts equine veterinarians regarding the importance of suspecting and investigating fungal co-infections in complicated cases of enterocolitis.

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马驹急性小肠结肠炎相关的系统性曲霉病

Aspergillosis在马身上是一种罕见的疾病，但它可能是致命的。我们报告了在巴西南部同一地区短时间内发生的两例小马驹系统性曲霉菌病。此外，还对类似病例进行了文献综述。风险因素归因于原发性小肠结肠炎和皮质类固醇治疗引起的免疫抑制、上皮损伤和多种抗菌治疗，这些治疗允许局部真菌增殖、组织侵袭和感染传播，导致死亡。由于小马驹曲霉菌病的尸检诊断很困难，我们的报告提醒马兽医怀疑和调查复杂小肠结肠炎病例中真菌合并感染的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal de mycologie medicale 医学-真菌学

CiteScore

5.10

自引率

2.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.