Up-to-date meta-analysis of long-term evaluations of mesenchymal stem cell therapy for complex perianal fistula.

IF 3.6 3区医学 Q3 CELL & TISSUE ENGINEERING

World journal of stem cells Pub Date : 2023-08-26 DOI:10.4252/wjsc.v15.i8.866

Fang Cheng, Huang Zhong, Zhong Huang, Zhi Li

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Abstract

Background: Local mesenchymal stem cell (MSC) therapy for complex perianal fistulas (PFs) has shown considerable promise. But, the long-term safety and efficacy of MSC therapy in complex PFs remain unknown.

Aim: To explore the long-term effectiveness and safety of local MSC therapy for complex PFs.

Methods: Sources included the PubMed, EMBASE, and Cochrane Library databases. A standard meta-analysis was performed using RevMan 5.3.

Results: After screening, 6 studies met the inclusion criteria. MSC therapy was associated with an improved long-term healing rate (HR) compared with the control condition [odds ratio (OR) = 2.13; 95% confidence interval (95%CI): 1.34 to 3.38; P = 0.001]. Compared with fibrin glue (FG) therapy alone, MSC plus FG therapy was associated with an improved long-term HR (OR = 2.30; 95%CI: 1.21 to 4.36; P = 0.01). When magnetic resonance imaging was used to evaluate fistula healing, MSC therapy was found to achieve a higher long-term HR than the control treatment (OR = 2.79; 95%CI: 1.37 to 5.67; P = 0.005). There were no significant differences in long-term safety (OR = 0.77; 95%CI: 0.27 to 2.24; P = 0.64).

Conclusion: Our study indicated that local MSC therapy promotes long-term and sustained healing of complex PFs and that this method is safe.

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间充质干细胞疗法治疗复杂性肛周瘘长期评估的最新荟萃分析。

背景：间充质干细胞（MSC）局部疗法治疗复杂性肛周瘘管（PFs）已显示出相当大的前景。目的：探讨局部间充质干细胞治疗复杂肛瘘的长期有效性和安全性：资料来源包括 PubMed、EMBASE 和 Cochrane Library 数据库。采用RevMan 5.3进行标准荟萃分析：经过筛选，6 项研究符合纳入标准。与对照组相比，间充质干细胞疗法可提高长期愈合率（HR）[几率比（OR）= 2.13；95% 置信区间（95%CI）：1.34 至 3.38；P = 0.001]。与单纯纤维蛋白胶（FG）疗法相比，间充质干细胞加纤维蛋白胶疗法与长期HR改善相关（OR = 2.30；95%CI：1.21至4.36；P = 0.01）。当使用磁共振成像评估瘘管愈合情况时，发现间充质干细胞疗法的长期HR高于对照疗法（OR = 2.79；95%CI：1.37 至 5.67；P = 0.005）。长期安全性无明显差异（OR = 0.77；95%CI：0.27 至 2.24；P = 0.64）：我们的研究表明，局部间充质干细胞疗法可促进复杂性骨髓纤维瘤的长期和持续愈合，而且这种方法是安全的。

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来源期刊

World journal of stem cells Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

7.80

自引率

4.90%

发文量

750

期刊介绍： The World Journal of Stem Cells (WJSC) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of stem cells. It was launched on December 31, 2009 and is published monthly (12 issues annually) by BPG, the world''s leading professional clinical medical journal publishing company.