Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Wei Guo , Peiyao Ying , Ruiyang Ma , Zuoqian Jing , Gang Ma , Jin Long , Guichen Li , Zhe Liu
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引用次数: 0

Abstract

Pancreatic cancer is characterized by its high malignancy, insidious onset and poor prognosis. Most patients with pancreatic cancer are usually diagnosed at advanced stage or with the distant metastasis due to the lack of an effective early screening method. Liquid biopsy technology is promising in studying the occurrence, progression, and early metastasis of pancreatic cancer. In particular, exosomes are pivotal biomarkers in lipid metabolism and liquid biopsy of blood exosomes is valuable for the evaluation of pancreatic cancer. Lipid metabolism is crucial for the formation and activity of exosomes in the extracellular environment. Exosomes and lipids have a complex relationship of mutual influence. Furthermore, spatial metabolomics can quantify the levels and spatial locations of individual metabolites in cancer tissue, cancer stroma, and para-cancerous tissue in pancreatic cancer. However, the relationship among exosomes, lipid metabolism, and pancreatic cancer is also worth considering. This study mainly updates the research progress of metabolomics in pancreatic cancer, their relationship with exosomes, an important part of liquid biopsy, and their lipometabolic roles in pancreatic cancer. We also discuss the mechanisms by which possible metabolites, especially lipid metabolites through exosome transport and other processes, contribute to the recurrence and metastasis of pancreatic cancer.

Abstract Image

癌症脂肪代谢外泌体的液体活检分析。
癌症具有恶性程度高、发病隐匿、预后差等特点。由于缺乏有效的早期筛查方法,大多数癌症患者通常被诊断为晚期或远处转移。液体活检技术在研究癌症的发生、发展和早期转移方面具有很好的前景。特别是,外泌体是脂质代谢中的关键生物标志物,血液外泌体的液体活检对评估癌症有价值。脂质代谢对于外泌体在细胞外环境中的形成和活性至关重要。外泌体和脂质具有相互影响的复杂关系。此外,空间代谢组学可以量化癌症组织、癌症间质和癌症癌旁组织中个体代谢产物的水平和空间位置。然而,外泌体、脂质代谢和胰腺癌症之间的关系也值得考虑。本研究主要介绍癌症代谢组学的研究进展、代谢组学与液体活检重要组成部分外泌体的关系及其在癌症中的脂代谢作用。我们还讨论了可能的代谢产物,特别是通过外泌体转运和其他过程的脂质代谢产物,促进癌症复发和转移的机制。
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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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