Arterial Stiffness in Overweight and Obesity: Association with Sex, Age, and Blood Pressure.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE
John G Eikås, Eva Gerdts, Hilde Halland, Helga Midtbø, Dana Cramariuc, Ester Kringeland
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引用次数: 0

Abstract

Introduction: Obesity has been associated with increased arterial stiffness. Sex-differences in arterial stiffness in obesity have been less explored.

Aim: To explore sex-differences in arterial stiffness by applanation tonometry in 323 women and 225 with overweight and obesity, free of cardiovascular disease.

Methods: Covariables of arterial stiffness were identified in multivariable linear regression analyses in the total cohort and separately in women and men.

Results: In the total study cohort, women had higher augmentation pressure (AP) and augmentation index (AIx), and lower carotid-femoral pulse wave velocity (cf-PWV) than men, independent of confounders (all p < 0.001). In sex-specific analyses, higher AP was associated with higher age and 24-hours systolic blood pressure (BP), and with lower heart rate in women (all p < 0.001), and with higher age and BP in men (all p < 0.001). Similarly, higher AIx was associated with higher age and BP, and lower body mass index (BMI) and heart rate in women (all p < 0.05), and with higher age in men (all p < 0.001). Higher cf-PWV correlated with higher age and BP in women (all p < 0.005), and additionally with higher heart rate and non-smoking in men (all p < 0.05). When replacing BMI with waist-hip ratio, higher waist-hip ratio was associated with higher cf-PWV in men only (p < 0.05).

Conclusions: Among subjects with overweight and obesity, AP and AIx were higher in women, and cf-PWV was higher in men. Age and 24-hours systolic BP were the main factors associated with arterial stiffness in both sexes, while measures of adiposity had little impact on arterial stiffness.

Abstract Image

Abstract Image

超重和肥胖的动脉僵硬:与性别、年龄和血压的关系。
引言:肥胖与动脉硬化增加有关。肥胖患者动脉硬化的性别差异研究较少。目的:探讨323名超重和肥胖、无心血管疾病的女性和225名超重和超重和肥胖女性动脉硬化的性别差异。方法:在总队列中以及在女性和男性中分别进行多变量线性回归分析,以确定动脉硬化的共变量。结果:在整个研究队列中,女性的增强压(AP)和增强指数(AIx)高于男性,颈动脉-股动脉脉搏波速度(cf-PWV)低于男性,与混杂因素无关(均p 结论:在超重和肥胖的受试者中,女性的AP和AIx较高,男性的cf PWV较高。年龄和24小时收缩压是男女动脉硬化的主要因素,而肥胖程度对动脉硬化的影响很小。
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来源期刊
CiteScore
5.70
自引率
3.30%
发文量
57
期刊介绍: High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes:   Invited ''State of the Art'' reviews.  Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.
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